Correlations of serum cell division cycle 42, β<sub>2</sub>-microglobulin and fibulin 1 levels with abdominal aortic calcification in patients with maintenance hemodialysis

YAN Junfang; ZONG Qian; YUAN Liang; BAO Ting; XU Wenting

doi:10.7619/jcmp.20241906

Journal of Clinical Medicine in Practice > 2024 > 28(18): 47-50. > DOI: 10.7619/jcmp.20241906

YAN Junfang, ZONG Qian, YUAN Liang, BAO Ting, XU Wenting. Correlations of serum cell division cycle 42, β₂-microglobulin and fibulin 1 levels with abdominal aortic calcification in patients with maintenance hemodialysis[J]. Journal of Clinical Medicine in Practice, 2024, 28(18): 47-50. DOI: 10.7619/jcmp.20241906

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Correlations of serum cell division cycle 42, β₂-microglobulin and fibulin 1 levels with abdominal aortic calcification in patients with maintenance hemodialysis

1.
Department of Nephrology, the Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601
2.
Blood Purification Center, Hefei Fifth People's Hospital, Hefei, Anhui, 230011

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Received Date: May 08, 2024
Revised Date: July 16, 2024

Graphical Abstract

Abstract

Abstract

Objective
To investigate the correlations of serum cell division cycle 42 (CDC-42), β₂-microglobulin (β₂-MG) and fibulin 1 (FBLN1) levels with abdominal aortic calcification (AAC) in patients with maintenance hemodialysis (MHD).
Methods
General information and biochemical indicators of 74 MHD patients were collected, and they were divided into no to mild AAC group (n=36) and moderate to severe AAC group (n=38) based on the Abdominal Aortic Calcification Score (AACs). Serum levels of CDC-42, β₂-MG and FBLN1 were compared between the two groups, and multivariate Logistic regression analysis was used to explore the risk factors for AAC in MHD patients.
Results
The dialysis vintage, serum phosphorus, intact parathyroid hormone (iPTH), CDC-42, β₂-MG and FBLN1 levels in the moderate to severe AAC group were significantly higher than those in the no to mild AAC group (P < 0.05). AAC in MHD patients was positively correlated with serum phosphorus, iPTH, CDC-42, β₂-MG, FBLN1, and dialysis vintage (P < 0.05). High levels of CDC-42, β₂-MG and FBLN1 as well as long dialysis vintage were independent risk factors for AAC in MHD patients (P < 0.05).
Conclusion
Serum CDC-42, β₂-MG and FBLN1 levels are positively correlated with AAC in MHD patients. High levels of CDC-42, β₂-MG and FBLN1 as well as long dialysis vintage are independent risk factors for AAC in MHD patients.
- maintenance hemodialysis,
- cell division cycle 42,
- β₂-microglobulin,
- fibulin 1,
- abdominal aortic calcification,
- correlation

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References (23)

References

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Correlations of serum cell division cycle 42, β₂-microglobulin and fibulin 1 levels with abdominal aortic calcification in patients with maintenance hemodialysis

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Correlations of serum cell division cycle 42, β₂-microglobulin and fibulin 1 levels with abdominal aortic calcification in patients with maintenance hemodialysis