Serological predictors of poor prognosis in patients with chronic heart failure

SUI Yong; SUN Hui; YAO Chuanwei; SHI Min; YU Jun

doi:10.7619/jcmp.20212165

Journal of Clinical Medicine in Practice > 2021 > 25(21): 52-57. > DOI: 10.7619/jcmp.20212165

SUI Yong, SUN Hui, YAO Chuanwei, SHI Min, YU Jun. Serological predictors of poor prognosis in patients with chronic heart failure[J]. Journal of Clinical Medicine in Practice, 2021, 25(21): 52-57. DOI: 10.7619/jcmp.20212165

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Serological predictors of poor prognosis in patients with chronic heart failure

1.
Department of Cardiology, Liaocheng Hospital of Traditional Chinese Medicine in Shandong Province, Liaocheng, Shandong, 252000
2.
Hemodialysis Room, Liaocheng Hospital of Traditional Chinese Medicine in Shandong Province, Liaocheng, Shandong, 252000

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Received Date: May 24, 2021
Available Online: December 02, 2021
Published Date: November 14, 2021

Graphical Abstract

Abstract

Abstract

Objective To explore the serological predictors of poor prognosis in patients with chronic heart failure(CHF).
Methods A total of 145 newly diagnosed patients with CHF were recruited as group A, and 138 healthy volunteers were recruited as group B. Serum levels of soluble suppression of tumorigenicity 2 (sST2), growth differentiation factor 15 (GDF-15) and lonely G protein coupled receptor ligand-12 (Apelin-12) in both groups were detected; the predictive value of serum sST2, GDF-15 and Apelin-12 levels alone and their combination for poor prognosis in the group A was analyzed.
Results Two cases were lost during follow-up in the group A. The serum levels of sST2 and GDF-15 in the group A were significantly higher, and the level of Apelin-12 was significantly lower than that in the group B (P < 0.05). The incidence of poor prognosis in the group A was 44.06%, the levels of sST2 and GDF-15 in patients with poor prognosis were significantly higher than those in patients with good prognosis, and the level of Apelin-12 was significantly lower than those in patients with good prognosis (P < 0.05). Age, diabetes mellitus, hyperlipidemia, increased level of N-terminal prohormone B-type natriuretic peptide (NT-proBNP), sST2, GDF-15 and decreased level of Apelin-12 were the influencing factors of poor prognosis in the group A. The sensitivity of sST2, GDF-15 and APelin-12 levels combined to predict poor prognosis of CHF patients was significantly higher than those of single prediction (P < 0.01), and area under the curve (AUC) of receiver operating characteristic (ROC) was significantly higher than that of single prediction (P < 0.05).
Conclusion The serum levels of sST2 and GDF-15 are higher, and the serum levels of Apelin-12 is lower in patients with CHF. The above serum indexes, age and complications are related to the prognosis of patients, and the combination of these three factors a better efficacy in predicting poor prognosis of patients.

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References

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Serological predictors of poor prognosis in patients with chronic heart failure