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抑郁症与强迫症患者治疗前后血清脑源性神经营养因子、白介素-2及白介素-6水平变化及其临床意义

江鸿波, 李莉欣

江鸿波, 李莉欣. 抑郁症与强迫症患者治疗前后血清脑源性神经营养因子、白介素-2及白介素-6水平变化及其临床意义[J]. 实用临床医药杂志, 2013, (1): 37-40. DOI: 10.7619/jcmp.201301011
引用本文: 江鸿波, 李莉欣. 抑郁症与强迫症患者治疗前后血清脑源性神经营养因子、白介素-2及白介素-6水平变化及其临床意义[J]. 实用临床医药杂志, 2013, (1): 37-40. DOI: 10.7619/jcmp.201301011
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JIANG Hongbo, LI Lixin. The level changes of brain-derived neurotrophic factors, interleukin-2 and interleukin-6 in serum of patients with depression and obsessive-compulsive disorder before and after treatment and their clinical significance[J]. Journal of Clinical Medicine in Practice, 2013, (1): 37-40. DOI: 10.7619/jcmp.201301011
Citation: JIANG Hongbo, LI Lixin. The level changes of brain-derived neurotrophic factors, interleukin-2 and interleukin-6 in serum of patients with depression and obsessive-compulsive disorder before and after treatment and their clinical significance[J]. Journal of Clinical Medicine in Practice, 2013, (1): 37-40. DOI: 10.7619/jcmp.201301011
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抑郁症与强迫症患者治疗前后血清脑源性神经营养因子、白介素-2及白介素-6水平变化及其临床意义

  • 云南省泸西县人民医院神经内科,云南卢西,652400

基金项目: 中国高校医学期刊临床专项资金
详细信息

  • 中图分类号: R749

The level changes of brain-derived neurotrophic factors, interleukin-2 and interleukin-6 in serum of patients with depression and obsessive-compulsive disorder before and after treatment and their clinical significance

摘要

    摘要
  • 摘要: 目的 探讨抑郁症与强迫症患者治疗前后血清脑源性神经营养因子(BDNF)、白介素-2(IL-2)、白介素-6(IL-6)水平变化及影响因素.方法 患者按症状分为抑郁症组、强迫症组、对照组,每组30例.抑郁症组和强迫症组在帕罗西汀治疗基础上,配合心理治疗.酶联免疫吸附法(ELISA)检测3组血清BDNF、IL2、IL-6水平.治疗前后进行量表评定,抑郁症状评定采用汉密尔顿抑郁量表(HAMD),强迫症状评定采用耶鲁-布朗强迫量表(Y-BOCS).对抑郁症、强迫症患者血清BDNF、IL-2、IL-6水平与HAMD总分值、Y-BOCS总分值、病程、年龄、性别之间进行相关分析.结果 治疗后抑郁症组血清BDNF水平较治疗前明显升高,IL-2、IL-6水平较治疗前明显降低,但BDNF水平仍明显低于对照组.治疗后强迫症组血清BDNF水平较治疗前明显升高,IL-2水平较治疗前明显降低,但BDNF水平仍明显低于对照组.抑郁症组血清BDNF水平与HAMD评分呈负相关(P＜0.05),血清IL-2、IL-6水平与HAMD评分呈正相关.强迫症组血清BDNF水平与Y-BOCS评分呈负相关,血清IL-6与YBOCS评分呈正相关.结论 BDNF、IL-2、IL-6为抑郁症、强迫症的鉴别及诊疗提供可能依据.
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  • 发布日期:  2013-05-01

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