SHI Qianqian, LIU Jingjing. Risk factor and construction of nomogram prediction model for pertussis in children[J]. Journal of Clinical Medicine in Practice, 2025, 29(6): 56-61. DOI: 10.7619/jcmp.20244333
Citation: SHI Qianqian, LIU Jingjing. Risk factor and construction of nomogram prediction model for pertussis in children[J]. Journal of Clinical Medicine in Practice, 2025, 29(6): 56-61. DOI: 10.7619/jcmp.20244333

Risk factor and construction of nomogram prediction model for pertussis in children

  • Objective To explore the risk factors for pertussis in children and construct a nomogram prediction model for the risk of pertussis in children.
    Methods A total of 175 children with prolonged cough admitted from February to June 2024 were selected as modeling group and divided into pertussis group and control group based on whether pertussis was confirmed. The general conditions, clinical characteristics, and laboratory examination indicators of the two groups were compared. Logistic regression analysis was used to screen risk factors for pertussis in children, and a nomogram prediction model was constructed and internally validated. Additionally, 53 children with prolonged cough admitted from July to August 2024 were selected as validation group to externally validate the nomogram model.
    Results Among 175 children in the modeling group, 52 (29.71%) were diagnosed with pertussis. The proportions of children with poor indoor ventilation, contacting with coughing patients in 3 weeks before onset, passive smoking in 3 weeks before onset, and those who had not received the pertussis vaccine, as well as platelet levels, were higher in the pertussis group than in the control group (P < 0.05). Multivariate Logistic regression analysis showed that poor indoor ventilation, contacting with coughing patients in 3 weeks before onset, passive smoking in 3 weeks before onset, and not receiving the pertussis vaccine were independent risk factors for pertussis in children (OR=2.983, 4.943, 3.998, 5.943; P < 0.05). Based on these results, a nomogram model for predicting pertussis in children was constructed. The internal validation results showed that the area under the curve (AUC) of this nomogram model for predicting pertussis in children was 0.824, with a sensitivity of 82.70%, a specificity of 74.80%, and a goodness-of-fit Hosmer-Lemeshow test result of χ2=7.591, P=0.425. The external validation results showed an AUC of 0.799, with sensitivity of 80.80%, with specificity of 63.40%, and a goodness-of-fit Hosmer-Lemeshow test result of χ2=10.369, P=0.169.
    Conclusion Poor indoor ventilation, contacting with coughing patients in 3 weeks before onset, passive smoking in 3 weeks before onset, and not receiving the pertussis vaccine are independent risk factors for pertussis in children. The nomogram prediction model constructed based on these factors can effectively predict the risk of pertussis in children.
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