Efficacy of Xingpi Huazhuo Prescription in treating pre-diabetic patients with phlegm-dampness constitution and its influences on blood glucose and renal function indexes

Objective To investigate the efficacy of Xingpi Huazhuo Prescription in treating pre-diabetic patients with phlegm-damp constitution and its impacts on blood glucose levels and renal function indicators.

Methods A total of 104 pre-diabetic patients with phlegm-damp constitution admitted to the hospital between January 2021 and December 2023 were selected and randomly divided into western medicine group (n=52) and combined group (n=52) using a random number table method. The western medicine group received metformin treatment, while the combined group received metformin combined with Xingpi Huazhuo Prescription. Clinical efficacy was recorded after 3 months of treatment, and blood glucose indexes such as fasting blood glucose (FPG), glycated hemoglobin (HbA1c), and 2-h plasma glucose (2 hPG) levels, lipid indicatorstriglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and renal function indicators serum creatinine (Scr), urea nitrogen (BUN), β₂-microglobulin (β₂-MG) were compared before and after 3 months of treatment.

Results After 3 months of treatment, the total clinical effectiveness in the combined group was higher than that in the western medicine group (P < 0.05). After 3 months of treatment, the levels of FPG, HbA1c, and 2 hPG decreased in both groups, and the combined group showed lower levels than the western medicine group (P < 0.05). After 3 months of treatment, the levels of TG, TC, and LDL-C decreased in both groups compared with before treatment, and the combined group showed lower levels than the western medicine group (P < 0.05); the levels of HDL-C increased in both groups, and the combined group showed higher levels than the western medicine group (P < 0.05). After 3 months of treatment, the levels of Scr, BUN, and β₂-MG decreased in both groups, with the combined group showing lower levels than the western medicine group (P < 0.05).

Conclusion In pre-diabetic patients with phlegm-damp constitution, metformin combined with Xingpi Huazhuo Prescription can effectively improve blood glucose levels and exert renal protective effects.