Expression levels and clinical significance of serum angiotensinogen and amyloid 4 in patients with rheumatoid arthritis

LI Xiaojun; MA Qin; ZHANG Tongtong

doi:10.7619/jcmp.20232131

Journal of Clinical Medicine in Practice > 2023 > 27(21): 37-41. > DOI: 10.7619/jcmp.20232131

LI Xiaojun, MA Qin, ZHANG Tongtong. Expression levels and clinical significance of serum angiotensinogen and amyloid 4 in patients with rheumatoid arthritis[J]. Journal of Clinical Medicine in Practice, 2023, 27(21): 37-41. DOI: 10.7619/jcmp.20232131

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Expression levels and clinical significance of serum angiotensinogen and amyloid 4 in patients with rheumatoid arthritis

Department of Rheumatology and Immunology, Bozhou City People′s Hospital of Anhui Province, Bozhou, Anhui, 236800

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Received Date: July 03, 2023
Revised Date: September 05, 2023
Available Online: November 23, 2023

Graphical Abstract

Abstract

Abstract

Objective
To investigate the expression level and clinical significance of serum angiotensinogen (AGT) and amyloid 4 (SAA4) in patients with rheumatoid arthritis (RA).
Methods
A total of 43 RA patients in active period (active group) and 37 RA patients in remission period (remission group) were selected as research objects, and 40 patients with joint pain and swelling (non-RA group) and 43 healthy volunteers (control group) were selected as controls. Levels of serum AGT, SAA4 and inflammatory factors such as C reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were detected in all the groups. Pearson correlation test was used to analyze the correlations of serum AGT and SAA4 with inflammatory factors in RA patients; the multivariate Logistic regression model was used to analyze the relationships of serum AGT and SAA4 with the occurrence of RA; the receiver operating characteristic (ROC) curve was used to analyze the values of serum AGT and SAA4 levels in diagnosing RA.
Results
Levels of serum AGT, SAA4, CRP, TNF-α and IL-6 and the Disease Activity Score-28 items (DAS28) score in the active and the remission groups were significantly higher than those in the non-RA and the control groups, and levels of serum AGT, SAA4, CRP, TNF-α and IL-6 and DAS28 in the active group were also significantly higher than those in the remission group (P < 0.05). Pearson correlation test showed that serum AGT and SAA4 were positively correlated with DAS28, CRP, TNF-α and IL-6 in RA patients (P < 0.05). Multivariate Logistic regression analysis showed that increased AGT and SAA4 were the independent risk factors for the occurrence of RA [OR(95%CI) were 1.247(1.108 to 1.405) and 1.131(1.042 to 1.227) respectively]. ROC curve analysis showed that the areas under the curve and its 95%CI [AUC(95%CI)] of serum AGT and SAA4 alone and their combination for the diagnosis of RA were 0.724(0.501 to 0.953), 0.778(0.600 to 0.932) and 0.862(0.773 to 0.925) respectively.
Conclusion
The elevated levels of serum AGT and SAA4 in RA patients are closely related to disease activity and inflammatory factors, and combined detection of serum AGT and SAA4 levels has high diagnostic value for RA.
- rheumatoid arthritis,
- angiotensinogen,
- serum amyloid 4,
- inflammatory factors

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References (24)

References

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Expression levels and clinical significance of serum angiotensinogen and amyloid 4 in patients with rheumatoid arthritis

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