Correlation between lipoprotein-associated phospholipase A2 level and cardiovascular disease in patients with obstructivesleep apnea syndrome

XU Meijie; QIAN Wenxia; XU Meihua; ZHANG Xun

doi:10.7619/jcmp.20223291

Journal of Clinical Medicine in Practice > 2023 > 27(3): 6-10. > DOI: 10.7619/jcmp.20223291

XU Meijie, QIAN Wenxia, XU Meihua, ZHANG Xun. Correlation between lipoprotein-associated phospholipase A2 level and cardiovascular disease in patients with obstructivesleep apnea syndrome[J]. Journal of Clinical Medicine in Practice, 2023, 27(3): 6-10. DOI: 10.7619/jcmp.20223291

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Correlation between lipoprotein-associated phospholipase A2 level and cardiovascular disease in patients with obstructivesleep apnea syndrome

1.
Department of Respiratory and Critical Care Medicine, Zhangjiagang Hospital Affiliated to Soochow University, Zhangjiagang, Jiangsu, 215600
2.
Nanjing Medical University, Nanjing, Jiangsu, 210009

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Received Date: November 03, 2022
Available Online: March 01, 2023

Graphical Abstract

Abstract

Abstract

Objective
To observe the level of lipoprotein-associated phospholipase A2 (Lp-PLA2) in peripheral blood of patients with obstructive sleep apnea syndrome (OSAS), and to explore whether Lp-PLA2 can be an effective predictor for patients with cardiovascular disease (CVD).
Methods
A total of 238 patients with suspected OSAS were selected as the research objects. According to the apnea hypopnea index (AHI), they were divided into non-OSAS group (n=53) and OSAS group (n=185) 42 mild cases, 68 moderate cases, and 75 severe cases). Among them, 74 patients with OSAS were complicated with CVD. The level of Lp-PLA2 in peripheral blood was determined by enzyme-linked immunosorbent assay (ELISA), and its relationship with CVD in patients with OSAS was analyzed.
Results
The age, AHI, oxygen desaturation index (ODI), Lp-PLA2 of OSAS patients with CVD were significantly higher than those of OSAS patients without CVD(P < 0.05). Among patients with mild, moderate and severe OSAS, the Lp-PLA2 level in patients with CVD was significantly higher than that in in patients without CVD (P < 0.05). The area under receiver operating characteristic (ROC) curve of Lp-PLA2 for predicting CVD in OSAS patients was 0.804 (0.740 to 0.859, P < 0.001), and the cut-off value was 235.1 ng/mL. Multivariate Logistic regression analysis showed that AHI (OR=1.044, 95%CI, 1.025 to 1.063, P < 0.001), ODI (OR=1.035, 95%CI, 1.020 to 1.050, P < 0.001), Lp-PLA2 (OR=2.700, 95%CI, 1.412 to 5.164, P=0.003) and hypertension (OR=2.648, 95%CI, 1.384 to 5.067, P=0.003) were independent influencing factors for CVD in OSAS patients.
Conclusion
Lp-PLA2 can be used as an effective predictor of OSAS patients complicated with CVD. Lp-PLA2>235.1 ng/mL indicates that patients have a higher risk of complicating CVD.
- lipoprotein-associated phospholipase A2,
- obstructive sleep apnea syndrome,
- cardiovascular disease,
- risk factor

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References (22)

References

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