Value of <sup>18</sup>F-FDG PET/CT Deauville score and ΔSUV<sub>max</sub> in evaluating medium-term prognosis of patients with chemotherapy for diffuse large B-cell lymphoma

ZHENG Lichun; ZHANG Huan; GU Cheng; ZHANG Xiaoming; HAN Xue; ZHANG Zhi; HU Yueming; OUYANG Xiangliu

doi:10.7619/jcmp.20221851

Journal of Clinical Medicine in Practice > 2023 > 27(4): 85-90. > DOI: 10.7619/jcmp.20221851

ZHENG Lichun, ZHANG Huan, GU Cheng, ZHANG Xiaoming, HAN Xue, ZHANG Zhi, HU Yueming, OUYANG Xiangliu. Value of ¹⁸F-FDG PET/CT Deauville score and ΔSUV_max in evaluating medium-term prognosis of patients with chemotherapy for diffuse large B-cell lymphoma[J]. Journal of Clinical Medicine in Practice, 2023, 27(4): 85-90. DOI: 10.7619/jcmp.20221851

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Value of ¹⁸F-FDG PET/CT Deauville score and ΔSUV_max in evaluating medium-term prognosis of patients with chemotherapy for diffuse large B-cell lymphoma

1.
Department of Nuclear Medicine, Tangshan City Workers' Hospital, Tangshan, Hebei, 063000
2.
North China University of Science and Technology, Tangshan, Hebei, 063000
3.
the Second Department of Oncology, Tangshan City Workers' Hospital, Tangshan, Hebei, 063000
4.
Department of Pathology, Tangshan City Workers' Hospital, Tangshan, Hebei, 063000
5.
Department of Ultrasound Medicine, Tangshan City Workers' Hospital, Tangshan, Hebei, 063000

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Received Date: June 12, 2022
Available Online: March 05, 2023

Graphical Abstract

Abstract

Abstract

Objective
To explore the value of 18 fluoro-fluorodeoxyglucose positron emission tomography/computer tomography (¹⁸F-FDG PET/CT) display Deauville score and change of max standardized uptake value (ΔSUV_max) in evaluating medium-term prognosis of patients with chemotherapy for diffuse large B-cell lymphoma (DLBCL).
Methods
The ¹⁸F-FDG PET/CT images of 78 patients with DLBCL in the medium-term of chemotherapy were analyzed retrospectively. The receiver operating characteristic (ROC) curve was used to analyze the ΔSUV_max and ΔSUV_max%, the patients were divided into different groups according to optimal cut-off values of ΔSUV_max and ΔSUV_max% as well as Deauville score, and they were also divided into germinal center B-cell-like (GCB) type and non-GCB type. Kaplan-Meier survival curve and Cox regression analysis were performed to evaluate the ability of Deauville score and ΔSUV_max methods in prognosis.
Results
A total of 78 patients were divided into progressive group with 24 cases and non-progressive group with 54 cases; the mean value of ΔSUV_max was (3.42±9.90) in the progressive group, which was significantly lower than (8.76±5.58) in the non-progressive group (P < 0.05); the median value of ΔSUV_max% in the progressive group was 34.88%, which was significantly lower than 78.16% in the non-progressive group (P < 0.01). The area under the curve (AUC) of ΔSUV_max and ΔSUV_max% was 0.667 and 0.882 respectively (P < 0.01), and taking the cut-off values of 7.95 and 67.34% respectively as the grouping criteria, the Kaplan-Meier analysis showed that there were significant differences in 2-year progression-free survival (PFS) between groups (44.4% versus 82.4%, 33.3% versus 95.6%, P < 0.01). The 2-year PFS of Deauville < 4 (PET negative) group was 91.9%, which was significantly higher than 48.8% of Deauville≥4 (PET positive) group (P < 0.01). The 2-year PFS of GCB type was 90.3%, which was significantly higher than 55.3% of non-GCB type (P < 0.01). Cox multivariate analysis showed that ΔSUV_max% and immunohistochemical typing were the independent predictors (P < 0.01).
Conclusion
Both Deauville score and ΔSUV_max methods have high values in the medium-term prognostic evaluation of chemotherapy for DLBCL, and ΔSUV_max% and immunohistochemical typing were the independent predictors for PFS.

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References (19)

References

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Value of ¹⁸F-FDG PET/CT Deauville score and ΔSUV_max in evaluating medium-term prognosis of patients with chemotherapy for diffuse large B-cell lymphoma