WANG Milu, WU Haiying. Study on value of urinary gonadotropin in evaluating sexual development[J]. Journal of Clinical Medicine in Practice, 2022, 26(9): 124-129. DOI: 10.7619/jcmp.20214398
Citation: WANG Milu, WU Haiying. Study on value of urinary gonadotropin in evaluating sexual development[J]. Journal of Clinical Medicine in Practice, 2022, 26(9): 124-129. DOI: 10.7619/jcmp.20214398

Study on value of urinary gonadotropin in evaluating sexual development

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  • Received Date: November 07, 2021
  • Available Online: May 09, 2022
  • Published Date: May 14, 2022
  • Puberty development refers to the course of maturation from childhood to adulthood and is accompanied by a growth spurt, development of secondary sexual and finally acquisition of adult reproductive capacity. The onset of pubertal development is result of activation of the anterior pituitary to produce gonadotrophin after increase in gonadotrophin-releasing hormone pulsatility by activation of the hypothalamic-pituitary-gonadal axis, and the gonads then mature and produce sex steroid hormones. Studies have shown that gonadotropin concentration in serumincreases at night in prepuberty and throughout puberty. Urinary gonadotropin concentration is expected to reflect the increase of gonadotropin secretion in serum. The research mainly focused on the value of urinary gonadotropin in evaluating the progress of puberty development.
  • [1]
    JUUL A, HAGEN C P, AKSGLAEDE L, et al. Endocrine evaluation of reproductive function in girls during infancy, childhood and adolescence[J]. Endocr Dev, 2012, 22: 24-39. doi: 10.1159/000326625
    [2]
    FENICHEL P. Delayed puberty[J]. Endocr Dev, 2012, 22: 138-159. doi: 10.1159/000326686
    [3]
    SØRENSEN K, MOURITSEN A, AKSGLAEDE L, et al. Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty[J]. Horm Res Paediatr, 2012, 77(3): 137-145. doi: 10.1159/000336325
    [4]
    SHIM Y S, AN S H, LEE H J, et al. Random urinary gonadotropins as a useful initial test for girls with central precocious puberty[J]. Endocr J, 2019, 66(10): 891-903. doi: 10.1507/endocrj.EJ19-0071
    [5]
    DEMIR A, VOUTILAINEN R, STENMAN U H, et al. First morning voided urinary gonadotropin measurements as an alternative to the GnRH test[J]. Horm Res Paediatr, 2016, 85(5): 301-308. doi: 10.1159/000440955
    [6]
    DEMIR A, VOUTILAINEN R, JUUL A, et al. Increase in first morning voided urinary luteinizing hormone levels precedes the physical onset of puberty[J]. J Clin Endocrinol Metab, 1996, 81(8): 2963-2967.
    [7]
    曾春华, 王慕逖. 尿促性腺激素的测定及在儿科的应用[J]. 国外医学: 儿科学分册, 1993, 20(4): 185-187. https://www.cnki.com.cn/Article/CJFDTOTAL-GEKX199304005.htm
    [8]
    马亚萍. 儿童尿促性腺激素与发育[D]. 苏州: 苏州大学, 2016.
    [9]
    AKSGLAEDE L, JENSEN R B, CARLSEN E, et al. Increased basal and pulsatile secretion of FSH and LH in young men with 47, XXY or 46, XX karyotypes[J]. Eur J Endocrinol, 2008, 158(6): 803-810. doi: 10.1530/EJE-07-0709
    [10]
    谢书艳, 徐庄剑, 马亚萍, 等. 昼夜尿促性腺激素与儿童下丘脑-垂体-性腺轴启动的关系[J]. 实用儿科临床杂志, 2011, 26(20): 1560-1563. doi: 10.3969/j.issn.1003-515X.2011.20.008
    [11]
    王喜平. 在GnRHa激发试验中儿童尿促性腺激素(免疫化学发光法)动态观察[D]. 苏州: 苏州大学, 2010.
    [12]
    张婷婷. GnRHa激发试验时中枢性性早熟女童尿促性腺激素动态变化[D]. 苏州: 苏州大学, 2012.
    [13]
    王喜平, 徐庄剑, 马亚萍, 等. 尿促性腺激素检查在儿童促性腺激素释放激素类似物激发试验中的价值[J]. 实用儿科临床杂志, 2010, 25(20): 1550-1552, 1567.
    [14]
    陈烨, 王俊祺, 倪继红, 等. 定量测定尿促性腺激素判断女童性发育程度应用价值研究[J]. 中国实用儿科杂志, 2016, 31(3): 219-223. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSEK201603018.htm
    [15]
    CONE E J, CAPLAN Y H, FRANK M, et al. Normalization of urinary drug concentrations with specific gravity and creatinine[J]. J Anal Toxicol, 2009, 33(1): 1-7. doi: 10.1093/jat/33.1.1
    [16]
    BARR D B, WILDER L C, CAUDILL S P, et al. Urinary creatinine concentrations in the US population: implications for urinary biologic monitoring measurements[J]. Environ Health Perspect, 2005, 113(2): 192-200. doi: 10.1289/ehp.7337
    [17]
    WANG B, TANG C X, WANG H X, et al. Influence of body mass index status on urinary creatinine and specific gravity for epidemiological study of children[J]. Eur J Pediatr, 2015, 174(11): 1481-1489. doi: 10.1007/s00431-015-2558-9
    [18]
    SINGH G K S, BALZER B W R, DESAI R, et al. Requirement for specific gravity and creatinine adjustments for urinary steroids and luteinizing hormone concentrations in adolescents[J]. Ann Clin Biochem, 2015, 52(6): 665-671. doi: 10.1177/0004563215580385
    [19]
    贲泽. 0~6岁儿童尿促性腺激素、性激素变化趋势和特点[D]. 无锡: 江南大学, 2018.
    [20]
    DEMIR A, DUNKEL L, STENMAN U H, et al. Age-related course of urinary gonadotropins in children[J]. J Clin Endocrinol Metab, 1995, 80(4): 1457-1460.
    [21]
    DEMIR A, AYDIN A, BVYVKGEBIZ A, et al. Urinary gonadotropin measurements by enhanced luminometric assays (LIA) for the evaluation of pubertal development[J]. J Pediatr Endocrinol Metab, 2021, 34(7): 859-866. doi: 10.1515/jpem-2020-0598
    [22]
    SINGH G K S, BALZER B W R, KELLY P J, et al. Urinary sex steroids and anthropometric markers of puberty-A novel approach to characterising within-person changes of puberty hormones[J]. PLoS One, 2015, 10(11): e0143555. doi: 10.1371/journal.pone.0143555
    [23]
    LUCACCIONI L, MCNEILLY J, MASON A, et al. The measurement of urinary gonadotropins for assessment and management of pubertal disorder[J]. Horm Athens Greece, 2016, 15(3): 377-384.
    [24]
    MA Y P, NIE S, BEN Z, et al. The dynamic trends of urinary LH and FSH assayed by ICMA during triptorelin stimulation tests in girls-a pilot study[J]. Clin Lab, 2018, 64(10): 1701-1708.
    [25]
    BRIDGES N A, CHRISTOPHER J A, HINDMARSH P C, et al. Sexual precocity: sex incidence and aetiology[J]. Arch Dis Child, 1994, 70(2): 116-118. doi: 10.1136/adc.70.2.116
    [26]
    APTER D, CACCIATORE B, ALFTHAN H, et al. Serum luteinizing hormone concentrations increase 100-fold in females from 7 years of age to adulthood, as measured by time-resolved immunofluorometric assay[J]. J Clin Endocrinol Metab, 1989, 68(1): 53-57. doi: 10.1210/jcem-68-1-53
    [27]
    ROSENFIELD R L, HELKE J. Is an immunoassay available for the measurement of bioactive LH in serum?[J]. J Androl, 1992, 13(1): 1-10.
    [28]
    KOLBY N, BUSCH A S, AKSGLAEDE L, et al. Nocturnal urinary excretion of FSH and LH in children and adolescents with normal and early puberty[J]. J Clin Endocrinol Metab, 2017, 102(10): 3830-3838. doi: 10.1210/jc.2017-01192
    [29]
    MAESAKA H, SUWA S, TACHIBANA K, et al. Quantitation of urinary gonadotropins in normal children[J]. Pediatr Res, 1990, 28(4): 401-404. doi: 10.1203/00006450-199010000-00019
    [30]
    MAESAKA H, SUWA S, TACHIBANA K, et al. Monthly urinary LH and FSH secretory patterns in normal children and patients with sexual disorders[J]. Pediatr Res, 1990, 28(4): 405-410. doi: 10.1203/00006450-199010000-00021
    [31]
    APTER D, BVTZOW T L, LAUGHLIN G A, et al. Gonadotropin-releasing hormone pulse generator activity during pubertal transition in girls: pulsatile and diurnal patterns of circulating gonadotropins[J]. J Clin Endocrinol Metab, 1993, 76(4): 940-949.
    [32]
    LEE S Y, KIM J M, KIM Y M, et al. Single random measurement of urinary gonadotropin concentration for screening and monitoring girls with central precocious puberty[J]. Ann Pediatr Endocrinol Metab, 2021, 26(3): 178-184. doi: 10.6065/apem.2040208.104
    [33]
    马晓宇, 陆文丽, 倪继红, 等. 尿促性腺激素全定量测定在预测女童乳房早发育类型中的应用价值[J]. 诊断学理论与实践, 2019, 18(3): 291-295. https://www.cnki.com.cn/Article/CJFDTOTAL-ZDLS201903013.htm
    [34]
    ZHAN S M, HUANG K, WU W, et al. The use of morning urinary gonadotropins and sex hormones in the management of early puberty in Chinese girls[J]. J Clin Endocrinol Metab, 2021, 106(11): e4520-e4530. doi: 10.1210/clinem/dgab448
    [35]
    张婷婷, 徐庄剑, 马亚萍, 等. 夜尿促性腺激素检测对女童性早熟的诊断价值[J]. 实用临床医药杂志, 2012, 16(3): 47-49, 56. doi: 10.3969/j.issn.1672-2353.2012.03.014
    [36]
    YVCE Ö, BIDECI A, ÖELIK N, et al. Diagnostic value of urinary luteinizing hormone levels in the monitoring of precocious puberty treatment[J]. Arch Endocrinol Metab, 2020, 64(2): 121-127.
    [37]
    罗小平. 中枢性性早熟诊断与治疗共识(2015)[J]. 中华儿科杂志, 2015, 53(6): 412-418. doi: 10.3760/cma.j.issn.0578-1310.2015.06.004
    [38]
    ZUNG A, BURUNDUKOV E, ULMAN M, et al. The diagnostic value of first-voided urinary LH compared with GNRH-stimulated gonadotropins in differentiating slowly progressive from rapidly progressive precocious puberty in girls[J]. Eur J Endocrinol, 2014, 170(5): 749-758. doi: 10.1530/EJE-14-0010
    [39]
    吴海瑛, 陈秀丽, 张丹丹. 尿促性腺激素测定在快进展青春期女童中的诊断意义[J]. 华南预防医学, 2019, 45(5): 453-456. https://www.cnki.com.cn/Article/CJFDTOTAL-GDWF201905015.htm
    [40]
    ZUNG A, BURUNDUKOV E, ULMAN M, et al. Monitoring gonadotropin-releasing hormone analogue (GnRHa) treatment in girls with central precocious puberty: a comparison of four methods[J]. J Pediatr Endocrinol Metab, 2015, 28(7/8): 885-893.
    [41]
    WITCHEL S F, BAENS-BAILON R G, LEE P A. Treatment of central precocious puberty: comparison of urinary gonadotropin excretion and gonadotropin-releasing hormone (GnRH) stimulation tests in monitoring GnRH analog therapy[J]. J Clin Endocrinol Metab, 1996, 81(4): 1353-1356.
    [42]
    BONCOMPAGNI A, MCNEILLY J, MURTAZA M, et al. Clinical utility of urinary gonadotrophins in hypergonadotrophic states as Turner syndrome[J]. J Pediatr Endocrinol Metab, 2020, 33(11): 1373-1381. doi: 10.1515/jpem-2020-0170
    [43]
    聂双. 小青春期尿促性腺激素和性激素特点及年龄界定探讨[D]. 无锡: 江南大学, 2019.
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