Relationships of expressions of soluble programmed death receptor-1 and interferon regulatory factor 4 with disease activity and immunoinflammation of patients with rheumatoid arthritis

HUANG Yanyan; LIN Shudian; ZHAN Feng; XIAO Lu; ZHAN Yuwei; MO Biyao; HAN Yeguang

doi:10.7619/jcmp.20214386

Journal of Clinical Medicine in Practice > 2022 > 26(11): 118-121, 137. > DOI: 10.7619/jcmp.20214386

HUANG Yanyan, LIN Shudian, ZHAN Feng, XIAO Lu, ZHAN Yuwei, MO Biyao, HAN Yeguang. Relationships of expressions of soluble programmed death receptor-1 and interferon regulatory factor 4 with disease activity and immunoinflammation of patients with rheumatoid arthritis[J]. Journal of Clinical Medicine in Practice, 2022, 26(11): 118-121, 137. DOI: 10.7619/jcmp.20214386

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Relationships of expressions of soluble programmed death receptor-1 and interferon regulatory factor 4 with disease activity and immunoinflammation of patients with rheumatoid arthritis

1.
Department of Rheumatology and Immunology, Hainan General Hospital, Hainan Hospital Affiliated to Hainan Medical University, Haikou, Hainan, 570311
2.
Laboratory Department, Hainan General Hospital, Hainan Hospital Affiliated to Hainan Medical University, Haikou, Hainan, 570311

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Received Date: November 07, 2021
Available Online: June 01, 2022

Graphical Abstract

Abstract

Abstract

Objective
To detect the expressions of soluble programmed death receptor-1 (sPD-1) and interferon regulatory factor 4 (IRF4) in the serum of patients with rheumatoid arthritis (RA) and to explore their clinical significance.
Methods
A total of 100 RA patients (RA group) were selected as study objects, including 50 patients in remission stage (remission RA group) and 50 patients in active stage (active RA group). In addition, 50 patients with osteoarthritis (OA) who received treatment during the same period (OA group) and 50 healthy people who underwent physical examination (control group) were selected. The venous blood was collected, and serum was separated, and the expression levels of sPD-1, IRF4, interleukin-4 (IL-4), interleukin-17 (IL-17) and interferon gamma (IFN-γ) in serum of subjects were detected by enzyme-linked immunosorbent assay (ELISA), the correlations of serum sPD-1, IRF4 levels with serum IL-4, IL-17, IFN-γ levels in RA patients were analyzed by Pearson method.
Results
Compared with the control group, the levels of serum sPD-1, IRF4, IL-4, IL-17 and IFN-γ of subjects in the OA and RA groups were significantly increased (P < 0.05); compared with the OA group, the levels of serum sPD-1, IRF4, IL-4, IL-17, and IFN-γ in the RA group were significantly increased (P < 0.05); compared with the remission RA group, the levels of serum sPD-1 and IRF4 in the active RA group were significantly increased (P < 0.05); the level of serum sPD-1 in RA patients was positively correlated with the levels of serum IL-4, IL-17, and IFN-γ (P < 0.05); the level of serum IRF4 in RA patients were positively correlated with the levels of serum IL-4, IL-17 and IFN-γ (P < 0.05).
Conclusion
The expression levels of sPD-1 and IRF4 in the serum of RA patients are elevated, they are related to disease activity and abnormal levels of inflammatory factors in the patients, and have the potential to become new therapeutic targets.
- soluble programmed death receptor-1,
- interferon regulatory factor 4,
- rheumatoid arthritis,
- inflammatory factors

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References (18)

References

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Relationships of expressions of soluble programmed death receptor-1 and interferon regulatory factor 4 with disease activity and immunoinflammation of patients with rheumatoid arthritis

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