Value of thymic stromal lymphopoietin, toll-like receptor 2, and immunoglobulin E in predicting psoriasis eczema in children

LI Li; SUI Yaping; GENG Xuejing; YIN Baohui; ZHU Aiqing

doi:10.7619/jcmp.20213836

Journal of Clinical Medicine in Practice > 2022 > 26(7): 124-127. > DOI: 10.7619/jcmp.20213836

LI Li, SUI Yaping, GENG Xuejing, YIN Baohui, ZHU Aiqing. Value of thymic stromal lymphopoietin, toll-like receptor 2, and immunoglobulin E in predicting psoriasis eczema in children[J]. Journal of Clinical Medicine in Practice, 2022, 26(7): 124-127. DOI: 10.7619/jcmp.20213836

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Value of thymic stromal lymphopoietin, toll-like receptor 2, and immunoglobulin E in predicting psoriasis eczema in children

Yantai Affiliated Hospital of Binzhou Medical College, Yantai, Shandong, 264100

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Received Date: September 23, 2021
Available Online: April 14, 2022
Published Date: April 14, 2022

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Abstract

Abstract

Objective To value of thymic stromal lymphopoietin(TSLP), toll-like receptor 2(TLR2), and immunoglobulin E(IgE)in predicting psoriasis eczema in children.
Methods A total of 275 psoriasis vulgaris patients with blood heat syndrome were selected as study objects, and were divided into experimental group (n=125) and control group(n=150) according to whether eczema lesions occurred. The clinical data, TSLP, TLR2 and IgE expressions of the two groups were compared. Pearson correlation analysis was used to analyze the correlations of TSLP, TLR2 and IgE in the experimental group, and receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of TSLP, TLR2 and IgE in pediatric psoriatic eczema lesions.
Results There were no significant differences in age, gender, and psoriasis area and severity index (PASI) score between the two groups(P>0.05). The incidence of pruritus in the experimental group was 96.00% (120/125), which was higher than 76.67% (115/150) in the control group (P < 0.05). The expression levels of serum TSLP and TLR2 in the experimental group were higher than those in the control group (P < 0.05), while there was no significant difference in the IgE expression level between the two groups (P>0.05). There were significant positive correlations between TSLP and TLR2 (r=0.853, P < 0.001), between TLR2 and IgE (r=0.670, P < 0.001), and between TSLP and IgE (r=0.677, P < 0.001). ROC curve showed that the areas under the curve of TSLP, TLR2 and IgE in predicting pediatric psoriatic eczema lesions were 0.718, 0.752 and 0.565, respectively.
Conclusion Any two of TSLP, TLR2 and IgE in serum of patients with psoriasis and eczema are positively correlated, and the expression levels of TSLP and TLR2 are significantly higher than those in patients without eczema. TSLP and TLR2 can predict eczema lesions in psoriasis children, and TLR2 has a better prediction effect.
- thymic stromal lymphopoietin,
- toll-like receptor 2,
- immunoglobulin E,
- psoriasis,
- eczema lesions,
- blood heat syndrome

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[1]	于洒, 甄莉. 银屑病、慢性荨麻疹、湿疹与食物不耐受的相关性研究[J]. 中国现代医药杂志, 2018, 20(3): 8-10. doi: 10.3969/j.issn.1672-9463.2018.03.003
[2]	周瑞艳, 段冲, 冯艳, 等. 极性蛋白ASPP2在棘层肥厚型皮肤病组织中的表达[J]. 中国医学创新, 2018, 15(5): 26-29. doi: 10.3969/j.issn.1674-4985.2018.05.007
[3]	佟海英, 陈潮光, 乌吉斯古冷, 等. 蒙药孟根乌苏(水银)-18味丸治疗皮肤科疾病临床探讨[J]. 内蒙古医科大学学报, 2019, 41(3): 249-252, 255. https://www.cnki.com.cn/Article/CJFDTOTAL-NMYX201903008.htm
[4]	薛春苗, 华国栋, 付鹏, 等. 浅析蒲地蓝消炎口服液治疗皮肤病的临床应用[J]. 中国合理用药探索, 2020, 17(5): 44-46. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYYS202005012.htm
[5]	孙文启, 陈蕾, 郭新云. 继发于红皮病型银屑病的Kaposi水痘样疹1例[J]. 中国中西医结合皮肤性病学杂志, 2019, 18(1): 77-78. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXYD201901031.htm
[6]	佟海英, 陈潮光, 乌吉斯古冷, 等. 蒙药孟根乌苏(水银)-18味丸治疗皮肤科疾病临床探讨[J]. 内蒙古医科大学学报, 2019, 41(3): 249-252, 255. https://www.cnki.com.cn/Article/CJFDTOTAL-NMYX201903008.htm
[7]	高婷婷, 胡吉升, 覃莉. 钙调磷酸酶抑制剂外用后导致顽固性湿疹1例并文献复习[J]. 中国中西医结合皮肤性病学杂志, 2018, 17(4): 364-365. doi: 10.3969/j.issn.1672-0709.2018.04.026
[8]	王颖娟, 曹伟. 寻常型银屑病患者外周血单个核细胞miR-26a、TLR表达及其与疾病活动相关性[J]. 中国医师杂志, 2020, 22(3): 403-406, 411. doi: 10.3760/cma.j.cn431274-20190322-00320
[9]	王巧鱼. 复方甘草酸苷注射液治疗寻常型银屑病及湿疹皮炎的临床观察[J]. 中国民间疗法, 2019, 27(6): 45-46. https://www.cnki.com.cn/Article/CJFDTOTAL-ZMJL201906028.htm
[10]	郭岱炯, 杨玉峰, 黄艳红, 等. 健脾祛湿法在银屑病湿疹样变中的临床应用研究[J]. 广州中医药大学学报, 2019, 36(8): 1160-1164. https://www.cnki.com.cn/Article/CJFDTOTAL-REST201908011.htm
[11]	刘岳花, 卢凤艳, 陆东庆. 白细胞介素-17和23在湿疹患者血清中的表达及其临床意义[J]. 临床皮肤科杂志, 2018, 47(3): 157-159. https://www.cnki.com.cn/Article/CJFDTOTAL-LCPF201803007.htm
[12]	刘鸿伟, 窦进法, 张守民. 司库奇尤单抗治疗中重度斑块状银屑病的近期疗效及安全性观察[J]. 中华皮肤科杂志, 2020, 53(8): 651-653.
[13]	郑茗贞, 孙奉朝, 黄国栋, 等. 布地奈德联合维生素D₃治疗小儿哮喘的疗效观察及对外周血IgE、TSLP和TLRs水平的影响[J]. 当代医学, 2019, 25(6): 10-13. https://www.cnki.com.cn/Article/CJFDTOTAL-DDYI201906004.htm
[14]	贾倩楠, 晋红中, 刘跃华, 等. 北京协和医院29 987例皮肤活检组织的临床病理诊断构成[J]. 中华皮肤科杂志, 2020, 53(2): 117-120. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYU201812025.htm
[15]	张丽霞, 王倩, 赵蓓, 等. TLR2、TSLP、IL-4、IFN-γ在特应性皮炎小鼠模型中的表达及意义[J]. 成都医学院学报, 2019, 14(1): 21-24. https://www.cnki.com.cn/Article/CJFDTOTAL-CDYU201901005.htm

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Value of thymic stromal lymphopoietin, toll-like receptor 2, and immunoglobulin E in predicting psoriasis eczema in children

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