Prediction of survival in children with rhabdomyosarcoma after chemotherapy by three-dimensional radiology

PENG Yaozong; PENG Yuming; YIN Yiwei

doi:10.7619/jcmp.20213049

Journal of Clinical Medicine in Practice > 2022 > 26(2): 113-118. > DOI: 10.7619/jcmp.20213049

PENG Yaozong, PENG Yuming, YIN Yiwei. Prediction of survival in children with rhabdomyosarcoma after chemotherapy by three-dimensional radiology[J]. Journal of Clinical Medicine in Practice, 2022, 26(2): 113-118. DOI: 10.7619/jcmp.20213049

Citation:

PDF (2647 KB)

Prediction of survival in children with rhabdomyosarcoma after chemotherapy by three-dimensional radiology

1.
Department of Radiology, Hunan Children's Hospital, Changsha, Hunan, 410007
2.
the First Department of General Surgery, Hunan Children's Hospital, Changsha, Hunan, 410007

More Information

Received Date: July 28, 2021
Available Online: April 13, 2021
Published Date: January 27, 2022

Graphical Abstract

Abstract

Abstract

Objective To evaluate the survival situations of children with rhabdomyosarcoma (RMS) after chemotherapy predicted by three-dimensional radiology.
Methods A total of 66 patients with RMS who received chemotherapy were retrospectively analyzed. Four methods were used to measure the tumor size on magnetic resonance or computed tomography images before and after chemotherapy. Maximal diameter was measured with Response Evaluation Criteria in Solid Tumors (1D-RECIST); multiplying the two maximal diameters was calculated with World Health Organization (2D-WHO); multiplying the three maximal diameters was calculated with European pediatric soft tissue sarcoma Study Group (3D-EpSSG); a software-assisted volume assessment was measured with the 3D-Osirix. Patients were classified as responders or non-responders based on the proposed thresholds for each method. Tumor response was compared with survival using Kaplan-Meier plots, the log-rank test, and Cox's regression.
Results Kaplan-Meier results showed that among the three methods, 5-year event free survival (5y-EFS) responders were longer than non-responders, and the difference of 3D-EpSSG evaluation between responder and non-responder was better than 1D-RECIST or 2D-WHO (P_1D-RECIST=0.018, P_2D-WHO=0.007, P_3D-EpSSG and P_3D-OsiriX < 0.001). In terms of 5y-EFS between the two groups, the adjusted hazard ratio of 1D-RECIST was 3.57 (P=0.016), 5.05 for 2D-WHO (P=0.004), 14.40 for 3D-EpSSG (P < 0.001), and 11.60 for 3D-Osirix (P < 0.001).
Conclusion Early tumor response is confirmed as a significant prognostic factor in RMS, and 3D-EpSSG and 3D-Osirix methods are superior to 1D-RECIST and 2D-WHO in predicting survival after chemotherapy for RMS.
- pediatric department,
- imaging,
- rhabdomyosarcoma,
- response assessment,
- survival prediction,
- chemotherapy

FullText(HTML)

References (23)

References

[1]	BHAMBHVANI H P, ZAMORA A, SHKOLYAR E, et al. Development of robust artificial neural networks for prediction of 5-year survival in bladder cancer[J]. Urologic Oncology, 2020, 39(3): 7-12.
[2]	KERIN Û, WOLOHAN C, COOKE K. Rhabdomyosarcoma: an overview and nursing considerations[J]. Br J Nurs, 2018, 27(6): 328-332. doi: 10.12968/bjon.2018.27.6.328
[3]	ANTONI A J, WAGNER L M. Pursuing Precision: Receptor Tyrosine Kinase Inhibitors for Treatment of Pediatric Solid Tumors[J]. Cancers, 2021, 13(14): 3531-3536. doi: 10.3390/cancers13143531
[4]	夏天, 姚伟, 沈剑, 等. 单中心儿童横纹肌肉瘤临床特征及与预后相关性168例回顾性队列研究[J]. 中华小儿外科杂志, 2021, 42(8): 736-744. doi: 10.3760/cma.j.cn421158-20210421-00203
[5]	徐艳丽. 儿童横纹肌肉瘤预后因素分析[J]. 中国小儿血液与肿瘤杂志, 2017, 22(5): 272-276. doi: 10.3969/j.issn.1673-5323.2017.05.012
[6]	文圆, 张伟令, 张谊, 等. 儿童头颈部横纹肌肉瘤疾病进展的危险因素及预后分析[J]. 中华实用儿科临床杂志, 2021, 36(15): 1152-1156. doi: 10.3760/cma.j.cn101070-20210128-00124
[7]	张琳, 熊昊, 李建新, 等. 儿童横纹肌肉瘤预后模型的构建及验证[J]. 临床肿瘤学杂志, 2021, 26(7): 622-628. doi: 10.3969/j.issn.1009-0460.2021.07.008
[8]	刘燕飞, 张娜, 李娟, 等. 儿童骨外尤文肉瘤误诊病例临床病理分析[J]. 中华实用儿科临床杂志, 2020, 35(21): 1651-1655. doi: 10.3760/cma.j.cn101070-20191018-01014
[9]	周恒花, 汪洋, 李江, 等. 15例头颈部梭形细胞/硬化性横纹肌肉瘤的临床病理分析[J]. 中国口腔颌面外科杂志, 2019, 17(2): 181-185. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGKQ201902029.htm
[10]	EISENHAUER E A, THERASSE P, BOGAERTS J, et al. New response evaluation criteria in solid tumours: revised RECIST guideline (version 1. 1)[J]. Eur J Cancer, 2009, 45(2): 228-247. doi: 10.1016/j.ejca.2008.10.026
[11]	韩秀鑫, 张超, 陶芳, 等. 尤文肉瘤的治疗研究进展[J]. 重庆医学, 2019, 48(7): 1191-1195. https://www.cnki.com.cn/Article/CJFDTOTAL-CQYX201907027.htm
[12]	周莉, 方拥军, 芮耀耀, 等. 儿童横纹肌肉瘤临床治疗评估[J]. 临床儿科杂志, 2018, 36(8): 584-586. doi: 10.3969/j.issn.1000-3606.2018.08.004
[13]	SINGHAL S, GILL M, SRIVASTAVA C, et al. Simplifying Tumor Volume Estimation from Linear Dimensions for Intra-Cranial Lesions Treated with Stereotactic Radiosurgery[J]. J Med Phys, 2020, 45(4): 199-205. doi: 10.4103/jmp.JMP_56_20
[14]	黎凡, 林维文, 官国先, 等. MRI测量原发肿瘤体积对cT3期低位直肠癌预后指导价值研究[J]. 中国实用外科杂志, 2019, 39(4): 365-369. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGWK201904022.htm
[15]	GUO FQ. 3-D treatment planning system-Leksell Gamma Knife treatment planning system[J]. Medical dosimetry: official journal of the American Association of Medical Dosimetrists, 2018, 43(2): 177-183. doi: 10.1016/j.meddos.2018.03.001
[16]	AGHIGHI M, BOE J, ROSENBERG J, et al. Three-dimensional radiologic assessment of chemotherapy response in ewing sarcoma can be used to predict clinical outcome[J]. Radiology, 2016, 280(3): 905-915. doi: 10.1148/radiol.2016151301
[17]	SCHOOT R A, MCHUGH K, VAN RIJN R R, et al. Response assessment in pediatric rhabdomyosarcoma: can response evaluation criteria in solid tumors replace three-dimensional volume assessments[J]. Radiology, 2013, 269(3): 870-878. doi: 10.1148/radiol.13122607
[18]	DANTONELLO T M, STARK M, TIMMERMANN B, et al. Tumour volume reduction after neoadjuvant chemotherapy impacts outcome in localised embryonal rhabdomyosarcoma[J]. Pediatr Blood Cancer, 2015, 62(1): 16-23. doi: 10.1002/pbc.25207
[19]	CHUNG M H, GUPTA R K, HSUEH E, et al. Humoral immune response to a therapeutic polyvalent cancer vaccine after complete resection of thick primary melanoma and sentinel lymphadenectomy[J]. J Clin Oncol, 2003, 21(2): 313-319. doi: 10.1200/JCO.2003.10.068
[20]	EWIJK R V, VAARWERK B, BREUNIS W B, et al. The Value of Early Tumor Size Response to Chemotherapy in Pediatric Rhabdomyosarcoma[J]. Cancers, 2021, 13(3): 510-518. doi: 10.3390/cancers13030510
[21]	丁敏, 刘凌翔. 晚期软组织肉瘤的免疫治疗进展[J]. 实用临床医药杂志, 2019, 23(17): 1-5. doi: 10.7619/jcmp.201917001
[22]	GALLAMINI A, HUTCHINGS M, RIGACCI L, et al. Early interim 2-[18F]fluoro-2-deoxy-D-glucose positron emission tomography is prognostically superior to international prognostic score in advanced-stage Hodgkin's lymphoma: a report from a joint Italian-Danish study[J]. J Clin Oncol, 2007, 25(24): 3746-3752. doi: 10.1200/JCO.2007.11.6525
[23]	刘江华, 毛彦娜, 李彦格, 等. 36例儿童横纹肌肉瘤疗效分析[J]. 现代肿瘤医学, 2019, 27(9): 1598-1601. doi: 10.3969/j.issn.1672-4992.2019.09.031

[1]	ZHANG Pan, WEI Yuanyuan, WANG Hao, WANG Xianwei, LI Yanqing, SUN Xue. Effect of Callicarpa nudiflora on wound healing and PI3K/AKT/mTOR pathway by regulating M2 macrophage polarization in rats with diabetic foot ulcer[J]. Journal of Clinical Medicine in Practice, 2025, 29(4): 44-49, 54. DOI: 10.7619/jcmp.20243269
[2]	MUTALIFU Muredili, AIZEZI Abula, KUYAXI Pilidong, ZHANG Weina, YONG Jun. MicroRNA-299-3p regulates proliferation, invasion and migration of nasopharyngeal carcinoma through phosphatidylinositol 3-kinase/protein kinase B pathway[J]. Journal of Clinical Medicine in Practice, 2025, 29(3): 6-10, 16. DOI: 10.7619/jcmp.20243658
[3]	WU Lili, LIN Jingtao, ZHANG Yuancheng, ZHONG Peimin, TANG Jinsong, WANG Haibo. Mechanisms of mesenchymal stem cell-derived extracellular vesicles in improvement of renal injury in rats with diabetic nephropathy by regulating mammalian target of rapamycin/p70 ribosome protein S6 kinase/coiled-coil myosin-like Bcl-2-interacting protein pathway[J]. Journal of Clinical Medicine in Practice, 2024, 28(10): 51-57. DOI: 10.7619/jcmp.20232784
[4]	WANG Haitong, LIU Jianliang. Mechanism of naringin on retinal microvascular endothelial cells injury based on adenosine-monophosphate-activated protein kinase/mammalian target of rapamycin pathway[J]. Journal of Clinical Medicine in Practice, 2024, 28(3): 23-28. DOI: 10.7619/jcmp.20233233
[5]	LU Baode, WEI Liuxing, LI Zhenjie, LIN Zhidi, HUANG Yongping. Effects and mechanism of long non-coding RNA LINC02178 on proliferation, invasion and migration of bladder cancer cells[J]. Journal of Clinical Medicine in Practice, 2023, 27(10): 36-41. DOI: 10.7619/jcmp.20223660
[6]	YI Jinling, Tubikezi·YIBILI, Gulihumaer·AINIWAER, LA Xiaolin. Effect of TAM family receptor tyrosine kinases on signaling pathway of mammalian target of rapamycin in patients with endometriosis[J]. Journal of Clinical Medicine in Practice, 2023, 27(2): 7-12, 16. DOI: 10.7619/jcmp.20223087
[7]	WEN Bo, LIU Zixiang, ZHANG Ziyan, CHEN Jiawei, WANG Zhenglin, ZHOU Shaobo. Effect of overexpression of heparanase on proliferation of gallbladder cancer cells and PI3K/AKT signaling pathway[J]. Journal of Clinical Medicine in Practice, 2022, 26(2): 56-61. DOI: 10.7619/jcmp.20213823
[8]	WANG Hao, ZHAO Wei, SHI Lei. Expression of phosphatase and tension homology deleted on chromosome ten and phospho-protein kinase B protein in gastrointestinal stromal tumor and their effects on the prognosis of patients[J]. Journal of Clinical Medicine in Practice, 2021, 25(18): 53-59. DOI: 10.7619/jcmp.20210835
[9]	LIU Xuejian, WU Xia, LI Yuhua. Influence of CD47 expression regulated by PI3K/AKT pathway on the tumor invasiveness of glioblastoma[J]. Journal of Clinical Medicine in Practice, 2020, 24(7): 56-61. DOI: 10.7619/jcmp.202007017
[10]	CHEN Tong. Correlation between vascular endothelial growth factor, mammalian target of rapamycin and clinical stage, prognosis in patients with nasopharyngeal carcinoma[J]. Journal of Clinical Medicine in Practice, 2016, (7): 58-60. DOI: 10.7619/jcmp.201607017

Cited By

Cited by

Periodical cited type(3)

1.	纪会荣，曹宇鹏，师光永. CT在肺部小结节临床诊断中的应用价值. 影像研究与医学应用. 2024(08): 102-104 .
2.	刘旭俊，陈代标，黄春嘉. 不同性质孤立性肺小结节在高分辨率CT下边缘特征及内部特征的差异性分析. 现代医用影像学. 2024(06): 1018-1021 .
3.	刘丽，范春辉，温明毅，李存琪，王武章. 分析肺内小结节诊断期间行双针法CT引导下经皮肺穿刺活检的价值. 中国医疗器械信息. 2023(14): 25-27 .

Other cited types(0)

Get Citation

PDF

XML

Article views (231) PDF downloads (2) Cited by(3)

Turn off MathJax

Article Contents

Abstract

References

Prediction of survival in children with rhabdomyosarcoma after chemotherapy by three-dimensional radiology