Correlations between serum levels of brain natriuretic peptide, hypersensitive C-reactive protein as well as creatine kinase isoenzyme and prognosis of patients after percutaneous coronary intervention

GONG Xiaoyong; HU Xiaowei; HE Fei; HU Jianping

doi:10.7619/jcmp.20211053

Journal of Clinical Medicine in Practice > 2021 > 25(11): 72-76. > DOI: 10.7619/jcmp.20211053

GONG Xiaoyong, HU Xiaowei, HE Fei, HU Jianping. Correlations between serum levels of brain natriuretic peptide, hypersensitive C-reactive protein as well as creatine kinase isoenzyme and prognosis of patients after percutaneous coronary intervention[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 72-76. DOI: 10.7619/jcmp.20211053

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Correlations between serum levels of brain natriuretic peptide, hypersensitive C-reactive protein as well as creatine kinase isoenzyme and prognosis of patients after percutaneous coronary intervention

1.
Department of Cardiovasology, Huangshan People's Hospital of Anhui Province, Huangshan, Anhui, 245000
2.
Department of Cardiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230000

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Received Date: March 11, 2021
Available Online: June 14, 2021
Published Date: June 14, 2021

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Abstract

Abstract

Objective To investigate the correlations between serum brain natriuretic peptide (BNP), high-sensitivity C-reactive protein (hs-CRP), creatine kinase isoenzyme (CK-MB) and short-term prognosis in patients with acute myocardial infarction after percutaneous coronary intervention (PCI).
Methods A total of 182 patients with acute myocardial infarction who underwent PCI were selected as the study subjects, and were divided into poor prognosis group (n=58) and good prognosis group (n=124) according to the occurrence of adverse cardiovascular events within three months after the operation. The serum levels of BNP, hs-CRP and CK-MB were detected by enzyme-linked immunosorbent assay (ELISA); the serum BNP, hs-CRP and CK-MB levels in patients with poor prognosis were analyzed; the predictive value of serum BNP, hs-CRP, CK-MB levels on the poor prognosis of acute myocardial infarction after PCI were analyzed; the factors affecting the poor prognosis of patients with PCI were analyzed.
Results The serum levels of BNP, hs-CRP and CK-MB in poor prognosis group were significantly higher than those in good prognosis group (P < 0.05). Serum BNP was positively correlated with hs-CRP and CK-MB levels in patients with poor prognosis (r=0.527, P < 0.05; r=0.541, P < 0.05), there was a positive correlation between CK-MB and hs-CRP (r=0.511, P < 0.05). The area under the curve (AUC) of serum BNP, hs-CRP, CK-MB alone and their combination in predicting poor prognosis after PCI were 0.872, 0.763, 0.921, 0.949, respectively, the specificity were 87.9%, 82.3%, 94.4%, 93.5%, respectively, and the sensitivity was 74.1%, 63.8%, 81.0% and 87.9%, respectively. NP and CK-MB were independent risk factors for poor prognosis in patients with acute myocardial infarction after PCI (P < 0.05).
Conclusion Serum BNP, hs-CRP and CK-MB have a certain predictive effect on the poor prognosis of patients with acute myocardial infarction after PCI.

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References

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Correlations between serum levels of brain natriuretic peptide, hypersensitive C-reactive protein as well as creatine kinase isoenzyme and prognosis of patients after percutaneous coronary intervention

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