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CHEN Lei, XU Ziyu, XIE Shanghuang, YUAN Haitao, LI Bo, PENG Wenjun, CHEN Xin. Clinical value of multimodal cardiac magnetic resonance imaging in acute viral myocarditis[J]. Journal of Clinical Medicine in Practice, 2021, 25(9): 18-22. DOI: 10.7619/jcmp.20210522
Citation: CHEN Lei, XU Ziyu, XIE Shanghuang, YUAN Haitao, LI Bo, PENG Wenjun, CHEN Xin. Clinical value of multimodal cardiac magnetic resonance imaging in acute viral myocarditis[J]. Journal of Clinical Medicine in Practice, 2021, 25(9): 18-22. DOI: 10.7619/jcmp.20210522
shu

Clinical value of multimodal cardiac magnetic resonance imaging in acute viral myocarditis

  • 1.

    Department of Medical Imaging, Shenzhen Longgang Central Hospital, Shenzhen, Guangdong, 518000

  • 2.

    Department of Cardiovascular Medicine, Shenzhen Longgang Central Hospital, Shenzhen, Guangdong, 518000

  • 3.

    Medical Imaging Department, Bethune First Hospital of Jilin University, Changchun, Jilin, 130000

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  • Received Date: February 25, 2021
  • Available Online: May 20, 2021
  • Published Date: May 14, 2021
    Graphical Abstract
    • Abstract
  •   Objective  To explore the clinical value of multimodal cardiac magnetic resonance imaging (CMR) in acute viral myocarditis (AVM).
      Methods  A total of 60 patients with AVM were selected as observation group, and 40 healthy volunteers were selected as control group. Both groups underwent multimodal CMR examinations, and the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were detected. Receiver operating characteristic (ROC) curve was used to analyze the application value of multimodal CMR parameters in AVM diagnosis, and Pearson correlation was used to analyze the relationship between multimodal CMR parameters and levels of IL-6 and TNF-α.
      Results  The left ventricular end systolic volume (LVESV), left ventricular end diastolic volume (LVEDV), myocardial mass (MM), average T1 value, average T2 value, late gadolinium enhancement (LGE) volume, percentage of LGE to left ventricular mass, levels of IL-6 and TNF-α in the observation group were significantly higher than those in the healthy controls, peak time was longer than that in the control group, while ejection fraction (EF), cardiac output (CO), the area ratio under the myocardial perfusion curve and the relative peak signal intensity were significantly lower than those of the healthy controls (P < 0.05). Pearson correlation analysis
      results  showed that LVEDV, LVESV, MM, peak time, average T1 value, average T2 value, LGE volume, percentage of LGE to left ventricular mass were positively correlated with IL-6, TNF-α levels, while EF, CO, the area under the curve of myocardial perfusion and the relative peak signal intensity were negatively correlated with IL-6 and TNF-α levels (P < 0.05). ROC curve showed that EF, LVEDV, LVESV, CO, MM, the area under the curve of myocardial perfusion and the relative peak signal intensity, peak time, average T1 value, average T2 value, LGE volume, percentage of LGE to left ventricular mass had certain value in diagnosing AVM (AUC=0.747, 0.740, 0.823, 0.750, 0.743, 0.815, 0.796, 0.728, 0.851, 0.840, 0.750, 0.752, P < 0.01), and combined diagnostic value was higher(AUC=0.943, P < 0.01).
      Conclusion  Multimodal CMR can quickly and accurately diagnose AVM.
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    • References (14)
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