Advance Search
LI Binbin, HU Liqun, TAN Meihua, LAI Feimin. Effect observation of conbercept combined with atorvastatin in the treatment of hyperlipidemia complicated with diabetic macular edema[J]. Journal of Clinical Medicine in Practice, 2020, 24(22): 41-43. DOI: 10.7619/jcmp.202022011
Citation: LI Binbin, HU Liqun, TAN Meihua, LAI Feimin. Effect observation of conbercept combined with atorvastatin in the treatment of hyperlipidemia complicated with diabetic macular edema[J]. Journal of Clinical Medicine in Practice, 2020, 24(22): 41-43. DOI: 10.7619/jcmp.202022011
shu

Effect observation of conbercept combined with atorvastatin in the treatment of hyperlipidemia complicated with diabetic macular edema

  • Department of Ophthalmology, Ganzhou City People's Hospital in Jiangxi Province, Ganzhou, Jiangxi, 341000

More Information
  • Received Date: September 14, 2020
  • Available Online: December 21, 2020
  • Published Date: December 02, 2020
    Graphical Abstract
    • Abstract
  • Objective To observe the clinical effect of conbercept combined with atorvastatin in the treatment of hyperlipidemia complicated with diabetic macular edema. Methods Totally 94 type 2 diabetes patients complicated with hyperlipidemia, non-proliferative diabetic retinopathy, macular edema, and macular hard exudation were selected and randomly divided into observation group and control group, with 47 cases in each group. The control group was treated with laser photocoagulation, while the observation group was treated with intravitreal injection of conbercept combined with oral taken atorvastatin calcium tablets. The levels of total cholesterol(TC), triglycerides(TG), high-density lipoprotein cholesterol(HDL-C)and low-density lipoprotein cholesterol(LDL-C)before treatment and 6 months after treatment were compared between two groups, and changes in macular edema, exudation and visual acuity were analyzed. Results After treatment, the levels of TC, TG and LDL-C in both groups were significantly lower than those before treatment, while the HDL-C level was significantly higher than that before treatment, and the levels of TC, TG and LDL-C in the observation group were significantly lower than those in the control group, and the HDL-C level was significantly higher than that in the control group(P<0.05). After treatment, macular edema, macular hard exudation and best corrected visual acuity were improved in both groups, and these indexes in the observation group were significantly better than the control group(P<0.05). Conclusion Intravitreal injection of conbercept combined with oral taken atorvastatin calcium tablets can effectively improve blood lipid metabolism, reduce degrees of macular edema and macular hard exudation, and - improve visual acuity.
    • FullText(HTML)
    • References (12)
  • KAHNERT K, LUCKE T, HUBER R M, et al. Relationship of hyperlipidemia to comorbidities and lung function in COPD: Results of the COSYCONET cohort[J]. PLoS One, 2017, 12(5): e0177501.
    MATOGA M M, HOSSEINIPOUR M C, AGA E, et al. Hyperlipidaemia in HIV-infected patients on lopinavir/ritonavir monotherapy in resource-limited settings[J]. Antivir Ther, 2017, 22(3): 205-213.
    丁国鹏, 丁国龙, 雷姝, 等. 康柏西普联合577nm微脉冲激光治疗糖尿病性黄斑水肿临床观察[J]. 国际眼科杂志, 2015, 15(11): 1942-1944.
    THEODOSIS-NOBELOS P, PAPAGIOUVANNIS G, KOUROUNAKIS P N, et al. Active anti-inflammatory and hypolipidemic derivatives of lorazepam[J]. Molecules, 2019, 24(18): E3277-E3283.
    孙清磊, 罗媛媛, 宋颖, 等. 糖尿病性黄斑水肿的发病机制与治疗进展[J]. 中华老年多器官疾病杂志, 2015, 14(1): 33-38.
    郭永兰, 赵亮亮, 聂黎黎, 等. 糖尿病性黄斑水肿的发病机制及治疗进展[J]. 国际老年医学杂志, 2019, 40(2): 116-119.
    唐孟苏, 张淑琦, 马立威. 曲安奈德球周注射联合阈下值微脉冲激光对糖尿病性黄斑水肿的疗效观察[J]. 中国实用眼科杂志, 2018, 36(5): 364-367.
    姜林, 杨红, 张世慧. 曲安奈德玻璃体腔注射联合视网膜激光光凝术在糖尿病黄斑水肿患者中的临床应用及安全性评价[J]. 实用临床医药杂志, 2017, 21(5): 167-169.
    李文清, 宋艳萍, 丁琴. 康柏西普联合577 nm阈值下微脉冲激光光凝治疗糖尿病黄斑水肿的疗效观察[J]. 中华眼底病杂志, 2019, 35(2): 129-134.
    DEMIR V, DO?RU M T, EDE H, et al. The effects of treatment with atorvastatin versus rosuvastatin on endothelial dysfunction in patients with hyperlipidaemia[J]. Cardiovasc J Afr, 2018, 29(3): 162-166.
    王海山, 张海军, 李玉军, 等. 雷珠单抗玻璃体腔注射并激光光凝治疗糖尿病性黄斑水肿疗效观察[J]. 中国实用眼科杂志, 2015, 33(1): 25-29.
    张召弟, 郭晟, 李娟, 等. 康柏西普和雷珠单抗治疗弥漫性糖尿病性黄斑水肿的疗效比较[J]. 广西医学, 2018, 40(5): 500-502

    , 517.
    • Related Articles

  • Related Articles

    [1]XIONG Yongqun, HE Yushen, XIE Peiwen, ZHENG Yi, LIN Jianwei, LI Yuancun, ZHANG Guihua. Sensitivity and specificity of fundus photograph in detecting diabetic macular edema[J]. Journal of Clinical Medicine in Practice, 2023, 27(18): 44-48. DOI: 10.7619/jcmp.20232028
    [2]YU Xiaochen, Yimamu YIDAYITULA, CAI Ning, ZHANG Yonghui. Dynamic changes of serum neuron-specific enolase in patients with single traumatic subarachnoid hemorrhage and its value in predicting prognosis[J]. Journal of Clinical Medicine in Practice, 2021, 25(11): 8-12. DOI: 10.7619/jcmp.20201422
    [3]GAO Yan, LI Qin, GE Hongshan, BIAN Min, LIU Jianqin. Predictive value of prenatal ultrasonic graphic features combined with high risk factor score of placental implantation for placental implantation[J]. Journal of Clinical Medicine in Practice, 2021, 25(10): 112-115. DOI: 10.7619/jcmp.20210069
    [4]ZHAO Chenghua. Value of artificial intelligence assisted diagnostic system combined with CT test in diagnosis of pulmonary nodules[J]. Journal of Clinical Medicine in Practice, 2020, 24(19): 9-11. DOI: 10.7619/jcmp.202019003
    [5]WANG Ying, LIU Min. Value of video electroencephalogram combined with neuron specific enolase detection in the diagnosis of children with febrile convulsions[J]. Journal of Clinical Medicine in Practice, 2020, 24(9): 10-12. DOI: 10.7619/jcmp.202009003
    [6]JIANG Guoliang, WU Xiaojun. CT plain scan versus enhanced scan in the diagnosisof blunt abdominal trauma[J]. Journal of Clinical Medicine in Practice, 2019, 23(18): 22-24. DOI: 10.7619/jcmp.201918007
    [7]JIA Shujing, SHI Chunxia, LI Lihua. Clinical significance and changes of serum high-sensitivity Creactive protein and neuron-specific enolase in acute cerebral infarction patients with different risk factors[J]. Journal of Clinical Medicine in Practice, 2019, 23(10): 61-64. DOI: 10.7619/jcmp.201910017
    [8]MA Tianming, HAN Xianwei. Change and significance of serum neuron specific enolase level in patients with herpes zoster[J]. Journal of Clinical Medicine in Practice, 2017, (13): 100-102. DOI: 10.7619/jcmp.201713026
    [9]ZHANG Chao, LUO Ruizhen, LI Jingyan, CHEN Zhiqiang, WANG Yiping. Application of automated breast volume scanner in diagnosis of breast cancer[J]. Journal of Clinical Medicine in Practice, 2016, (23): 68-71. DOI: 10.7619/jcmp.201623020
    [10]LIU Chunxia, GU Meng, ZHANG Hong, HANG Gao. Detection of specific allergen in allergic children in Nantong region and its clinical significance[J]. Journal of Clinical Medicine in Practice, 2014, (9): 44-47. DOI: 10.7619/jcmp.201409012

  • Cited by

    Periodical cited type(17)

    1. 杨志国. 微创拔牙术治疗下颌低位阻生智齿的有效性及作用研究. 罕少疾病杂志. 2025(03): 40-42 .
    2. 金苏菊，李雪晶，刘凤林，朱晓洁. 规范化循证护理干预联合四手操作配合在下颌水平低位阻生智齿拔除术中的应用. 齐鲁护理杂志. 2024(06): 152-154 .
    3. 周芳，曾文玲. 循证护理联合规范化疼痛护理在低位阻生智齿拔除中的应用效果. 医疗装备. 2024(06): 123-125 .
    4. 吴康，王国栋. 微创拔牙术拔除下颌低位阻生智齿对疼痛程度的影响. 中国卫生标准管理. 2024(09): 123-127 .
    5. 方首镕，王晓云，雷雨露，宁润来，蒋宁宁. 下颌低位阻生智齿拔除应用CBCT介导超声骨刀的效果及对PTX3、MPO、PGE2的影响. 中国医学工程. 2023(02): 59-63 .
    6. 潘其达. 不翻瓣法配合涡轮机拔除下颌阻生智齿的应用效果及预后观察. 现代诊断与治疗. 2023(03): 428-430 .
    7. 王鑫，侍泉华. 浓缩生长因子在下颌阻生齿拔除术中的应用效果及对患者生活质量的影响. 中国美容医学. 2023(05): 142-145 .
    8. 王军，刘素芳，王会敏. 微创拔牙术治疗下颌复杂阻生牙的临床疗效. 深圳中西医结合杂志. 2023(08): 115-118 .
    9. 许慧英. 微创拔牙术在下颌阻生智齿拔除治疗中的应用及对患者拔牙后张口受限程度以及并发症情况的影响. 系统医学. 2023(08): 169-173 .
    10. 徐金伟，张琴，陈海苏，于保军，俞辉明. 高速涡轮钻联合超声骨刀对下颌低位阻生智齿拔除的效果. 中国医药导报. 2023(21): 129-132 .
    11. 杨剑. 微创拔牙器械配合高速涡轮牙钻拔牙法在下颌低位阻生智齿治疗中的效果评价. 中国医药科学. 2023(13): 195-198 .
    12. 邹雅琴，凌瑞，劳茉，王敬雯，栗璞. 微创拔牙术在下颌阻生智齿拔除中的应用价值. 实用临床医学. 2023(03): 74-77 .
    13. 张莉，闫召民，姚燕，王宇. 高速涡轮机联合微创拔牙刀在下颌阻生智齿中的应用及对疼痛程度、并发症的影响分析. 黑龙江医学. 2023(19): 2313-2315 .
    14. 王笑梅. 高速涡轮牙钻联合微创拔牙刀在阻生智齿拔除术中的应用效果. 医学信息. 2023(21): 118-121 .
    15. 沈博文. 微创拔牙与传统器械拔牙治疗下颌阻生智齿的疗效对比分析. 现代医学与健康研究电子杂志. 2022(03): 7-9 .
    16. 孙辉，陈志方，王晓东. 下颌水平低位阻生齿拔除术治疗下颌阻生第三磨牙对患者牙周健康状况的影响. 湖南师范大学学报(医学版). 2022(04): 74-77 .
    17. 杜文斌，曹玮奇，姚国华，张帅，李尔涛，任辉. 十字形分牙法在下颌水平低位阻生齿拔除中的临床效果分析. 中国美容医学. 2021(12): 105-108 .

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML
    Article views (393) PDF downloads (18) Cited by(17)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return