Advance Search
QIAO Bin. Efficacy and safety of Compound Huangdai Tablets combined with retinoic acid in treatment of patients with acute promyelocytic leukemia in maintenance phase[J]. Journal of Clinical Medicine in Practice, 2020, 24(12): 114-116. DOI: 10.7619/jcmp.202012032
Citation: QIAO Bin. Efficacy and safety of Compound Huangdai Tablets combined with retinoic acid in treatment of patients with acute promyelocytic leukemia in maintenance phase[J]. Journal of Clinical Medicine in Practice, 2020, 24(12): 114-116. DOI: 10.7619/jcmp.202012032
shu

Efficacy and safety of Compound Huangdai Tablets combined with retinoic acid in treatment of patients with acute promyelocytic leukemia in maintenance phase

  • Department of Hematology, Weinan City Central Hospital in Shaanxi Province, Weinan, Shaanxi, 714000

More Information
  • Received Date: April 15, 2020
    Graphical Abstract
    • Abstract
  • Objective To explore the efficacy and safety of Compound Huangdai Tablets combined with retinoic acid in treatment of patients with acute promyelocytic leukemia(APL)in maintenance phase. Methods Ninety APL patients were selected and randomly divided into control group and observation group, with 45 cases in each group. The control group was treated with sequential therapy of retinoic acid and arsenious acid, while the observation group was treated with sequential therapy of Compound Huangdai Tablets and retinoic acid. The therapeutic effect, metabolism levels of blood lipid indexes before and after treatment, and the incidence of adverse reactions were compared between the two groups. Results There were no significant differences in event-free survival rate, mortality and recurrence rate between the two groups(P>0.05). After treatment, the levels of total cholesterol(TC), low density lipoprotein cholesterol(LDL-C)and triglyceride(TG)in both groups increased significantly(P<0.05), and the levels of TC, LDL-C and TG in the observation group were significantly lower than those in the control group(P<0.05). The incidence rates of adverse reactions such as gastrointestinal discomfort, retinoic acid syndrome, damage of liver and kidney function, increase of intracranial pressure, dizziness and headache and joint pain in the control group were significantly higher than those in the observation group(P<0.05). Conclusion Compared with therapy of arsenious acid combined with retinoic acid, the Compound Huangdai Tablets combined with retinoic acid has a better therapeutic effect in the treatment of patients with APL in maintenance phase, which can correct the abnormal metabolism of blood lipid indexes.
    • FullText(HTML)
    • References (15)
  • 王克强, 亓云法, 王静, 等. 急性早幼粒细胞白血病细胞形态学分型临床意义分析[J]. 中华肿瘤防治杂志, 2014, 21(7): 538-542.
    薛白, 李靖, 王奔放. 急性早幼粒细胞白血病实验室诊断方法研究进展[J]. 实验与检验医学, 2016, 34(1): 44-47.
    董菊, 张晨妍, 许婧娴, 等. 复方黄黛片治疗急性早幼粒细胞白血病的疗效与安全性的系统评价[J]. 东南大学学报: 医学版, 2018, 37(6): 993-997.
    中华医学会血液学分会, 中国医师协会血液科医师分会. 中国急性早幼粒细胞白血病诊疗指南(2018年版)[J]. 中华血液学杂志, 2018, 39(3): 179-183.
    陈慧, 程月新, 陈天荣, 等. 亚砷酸治疗急性早幼粒细胞白血病的临床效果与不良反应分析[J]. 现代诊断与治疗, 2015, 26(22): 5122-5123.
    朱蓓, 段衍超, 王克强. 不同亚型急性早幼粒细胞白血病患者维甲酸受体α融合基因的表达分析[J]. 中华诊断学电子杂志, 2015, 3(1): 15-18.
    柳飞. 全反式维甲酸与三氧化二砷联合化疗治疗急性早幼粒细胞白血病的疗效分析[D]. 郑州: 郑州大学, 2016.
    南虎松, 金春姬, 刘红. 全反式维甲酸联合复方黄黛片序贯治疗小儿急性早幼粒细胞白血病的临床研究[J]. 中国现代医学杂志, 2014, 24(36): 105-108.
    王会朋, 刘海英. 复方黄黛片联合全反式维甲酸治疗老年急性早幼粒细胞白血病的临床观察[J]. 陕西中医, 2016, 37(3): 313-314.
    胡爽, 王文静, 郭美华, 等. 亚砷酸治疗急性早幼粒细胞白血病患者血中总砷及砷形态测定[J]. 中国药师, 2018, 21(1): 23-27.
    王晓东, 刘传绪, 张倩, 等. 复方黄黛片联合全反式维甲酸治疗急性早幼粒细胞白血病的效果观察[J]. 解放军预防医学杂志, 2019, 37(8): 79-80.
    王修平. 复方黄黛片应用于急性早幼粒细胞白血病维持期治疗中临床对照观察[D]. 广州: 广州中医药大学, 2013.
    吴晓丹. 全反式维甲酸联合三氧化二砷治疗初发急性早幼粒细胞白血病的近期疗效分析[J]. 中国医药指南, 2018, 16(1): 96-97.
    朱淑芳, 王耀华. 复方黄黛片诱导治疗急性早幼粒细胞白血病的效果观察[J]. 中国药物经济学, 2014, 9(S1): 134-135.
    黄垚, 刘烨, 王玮. 全反式维甲酸联合三氧化二砷治疗初诊急性早幼粒细胞白血病的疗效及对复发率的影响分析[J]. 癌症进展, 2016, 14(7): 654-656

    , 660.
    • Related Articles

  • Related Articles

    [1]YANG Mei, PEI Bo, CHEN Dian. Effect of selenium yeast on short-term efficacy in concurrent chemoradiotherapy for cervical cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(22): 35-37. DOI: 10.7619/jcmp.20211191
    [2]PEI Bo, CHEN Jiaquan, DUAN Chunyan, YANG Mei, HE Du, CHEN Dian. Efficacy and safety of lobaplatin combined with radiotherapy versus cisplatin plus radiotherapy for locally advanced cervical cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(6): 106-109. DOI: 10.7619/jcmp.20201865
    [3]LIU Chunmei, LI Ming, ZHAO Gang. A systematic analysis in efficacy and safety of nimotuzumab combined with concurrent chemoradiotherapy in treatment of advanced esophageal cancer[J]. Journal of Clinical Medicine in Practice, 2021, 25(5): 10-15. DOI: 10.7619/jcmp.20201731
    [4]LI Hongzhi, WANG Honggang. Clinical effect of preoperative concurrent chemoradiotherapy with oxaliplatin and capecitabine in treatment of patients with medium to advanced rectal cancer[J]. Journal of Clinical Medicine in Practice, 2019, 23(23): 51-54. DOI: 10.7619/jcmp.201923015
    [5]LIU Fan, WANG Dan, ZHENG Xu. Effect of concurrent chemoradiothrapy on squamous cell carcinoma antigen and carcinoembryonic antigen levelsin patients with intermediate-advanced cervical cancer[J]. Journal of Clinical Medicine in Practice, 2019, 23(18): 36-38. DOI: 10.7619/jcmp.201918011
    [6]GENG Wei, ZHOU Jundong, CAO Haiying. Effect comparison between weekly cisplatin chemotherapy and paclitaxel liposome plus concurrent radiotherapy in the treatment of patients with middle and advanced cervical cancer[J]. Journal of Clinical Medicine in Practice, 2015, (24): 53-55. DOI: 10.7619/jcmp.201524016
    [7]FU Juan, ZHANG Aiyun, DU Junhua, OU Baoquan, YIN Yifa. Effect observation of concurrent radiochemotherapy combined with deep hyperthermia in treatment of patients with locally advanced cervical cancer[J]. Journal of Clinical Medicine in Practice, 2015, (13): 59-61,65. DOI: 10.7619/jcmp.201513018
    [8]ZHANG Jingyi, HU Yongsheng, ZHANG Hongjun, WANG Xi, SHI Guobing. Application of nedaplatin and paclitaxel in the concurrent radiochemotherapy of cervical carcinoma[J]. Journal of Clinical Medicine in Practice, 2014, (7): 88-90. DOI: 10.7619/jcmp.201407029
    [9]JIN HONG, ZHANG Yunyan, LI Qi. Therapeutic effect of concurrent chemoradiotherapy combined with sodium cantharidate vitamin B6 injection for advanced cervical cancer[J]. Journal of Clinical Medicine in Practice, 2013, (19): 149-151. DOI: 10.7619/jcmp.201319057
    [10]TIAN Xiu-mei. Nursing of radiotherapy combined with concurrent chemotherapy by low dose 5- Fu plus Cisplatin in advanced uterine cervical cancer[J]. Journal of Clinical Medicine in Practice, 2012, (2): 13-16. DOI: 10.3969/j.issn.1672-2353.2012.02.006

  • Cited by

    Periodical cited type(21)

    1. 喻洁明，任荣飞，陈晓亮. 耳内镜下应用耳屏软骨-软骨膜复合体行Ⅰ型鼓室成形术的临床疗效研究. 中国医学文摘(耳鼻咽喉科学). 2024(01): 130-132+108 .
    2. 黄献明，覃雪君，谭宇敏. 干湿耳状态下耳内镜下耳屏软骨-软骨膜Ⅰ型鼓室成形术远期疗效比较. 实用医院临床杂志. 2024(05): 157-160 .
    3. 徐美玲，林金成. 内镜下鼓室成形术治疗慢性化脓性中耳炎的效果. 中国当代医药. 2022(06): 89-91 .
    4. 杨礼宏，陈登胜，刘忠意，袁树金. 耳内镜下嵌入蝶形软骨鼓膜成形术治疗鼓膜前缘穿孔效果及对患者听力恢复的影响. 临床和实验医学杂志. 2021(01): 107-110 .
    5. 颜挺. 耳内镜下鼓膜成形术治疗慢性化脓性中耳炎的疗效观察. 临床研究. 2021(08): 17-18 .
    6. 尹新平，李玎，彭敏，刘璐璐，张红. 完桥式鼓室成形术治疗慢性中耳乳突炎临床应用. 中国药物与临床. 2021(16): 2816-2818 .
    7. 唐强，蒋中莉，禹林，梁绍伟，王智勇. 耳内镜下应用耳屏软骨-软骨膜复合体行Ⅰ鼓室成型术的效果研究. 系统医学. 2021(16): 38-40 .
    8. 刘武科. 耳内镜下鼓室成形术后鼓膜穿孔再修补的临床疗效观察. 医学食疗与健康. 2020(01): 69+72 .
    9. 徐继峰，李巍. 耳内镜下耳屏软骨—软骨膜修补鼓膜大穿孔临床疗效. 中国医学文摘(耳鼻咽喉科学). 2020(01): 43-45+4 .
    10. 刘文波，张丽华，李敏，孙青. 耳内镜下与耳科显微镜下鼓膜修补术的临床应用比较. 中国医药指南. 2020(12): 71-72 .
    11. 胡连德. 应用耳屏软骨与软骨膜复合体行耳内镜下修补鼓膜术的效果. 黑龙江医药. 2020(03): 675-677 .
    12. 李和，吴小娟，唐泺，樊利，曹刘. 耳内镜下应用耳屏软骨-软骨膜复合体行鼓室成型术的临床效果. 中国医学文摘(耳鼻咽喉科学). 2020(05): 368-369 .
    13. 张映国，陈胜津，陈丽芬，黄辉强，刘扬，卓芳年. 耳内镜下应用耳屏软骨-软骨膜复合体行Ⅰ型鼓室成形术的临床疗效研究. 中国实用医药. 2020(31): 37-39 .
    14. 林碧玉，李瑞玉，王一红. 耳内镜下与显微镜下鼓膜修补术的临床应用对比. 中国医学创新. 2020(35): 44-47 .
    15. 包勇正，邹文兰，胡志邦，马敬. 29例鼓膜大穿孔患者耳内镜下鼓膜成形术疗效观察. 实用临床医药杂志. 2020(23): 42-44 . 本站查看
    16. 熊斌，张小安，赖文敏，陈庭辉，王跃武. 显微镜联合耳内镜在鼓室成形术中的临床应用. 中国现代医生. 2020(32): 85-88 .
    17. 苏宏钊，廖海石，唐国鹏，林云雁. 耳内镜下采用耳屏软骨-软骨膜修补鼓膜穿孔的疗效观察. 临床医学. 2019(06): 52-54 .
    18. 邸远志，闫辉，周雪芳，吴照红. 耳内镜下Ⅰ型鼓室成形干湿耳手术199例疗效观察. 中国处方药. 2019(10): 145-146 .
    19. 闫强. 耳内镜下耳屏软骨-软骨膜复合体行鼓室成形术对鼓膜愈合及听力恢复影响效果. 中国疗养医学. 2019(10): 1077-1079 .
    20. 王龙海. 耳内镜与显微镜下分别行耳屏软骨环-软骨膜修补术治疗鼓膜穿孔对比观察. 中国疗养医学. 2019(10): 1082-1084 .
    21. 操启友. 耳内镜与显微镜下鼓膜修补术治疗慢性化脓性中耳炎鼓膜穿孔的疗效比较. 中国医学创新. 2019(30): 69-72 .

    Other cited types(0)

Catalog

    Get Citation
    PDF
    XML
    Article views (433) PDF downloads (14) Cited by(21)
    Turn off MathJax
    Article Contents
    Abstract
    References
    Related Articles

    © 2020 《实用临床医药杂志》编辑部

    Address: 江苏省扬州市江阳中路136号，扬州大学江阳路北校区14号楼201室China Pos: 225009Tel: 0514-87978917、87978989、87978807

    苏公网安备 32100302010246号

    Supported by: Beijing Renhe Information Technology Co., Ltd.   Baidu Analytics

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return