Effect of laparoscopic cholecystectomy on intestinal barrier function in patients with cholelithiasis complicated with diabetes mellitus

HUA Wenqiang; KONG Zhenyu; ZHANG Fugang

doi:10.7619/jcmp.20200765

Journal of Clinical Medicine in Practice > 2021 > 25(2): 67-69. > DOI: 10.7619/jcmp.20200765

HUA Wenqiang, KONG Zhenyu, ZHANG Fugang. Effect of laparoscopic cholecystectomy on intestinal barrier function in patients with cholelithiasis complicated with diabetes mellitus[J]. Journal of Clinical Medicine in Practice, 2021, 25(2): 67-69. DOI: 10.7619/jcmp.20200765

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Effect of laparoscopic cholecystectomy on intestinal barrier function in patients with cholelithiasis complicated with diabetes mellitus

Department of General Surgery, The Fifth People′s Hospital of Jiangyin City in Jiangsu Province, Jiangyin, Jiangsu, 214415

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Received Date: November 18, 2020
Available Online: January 26, 2021
Published Date: January 27, 2021

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Abstract

Abstract

Objective To observe the changes of intestinal barrier function in patients with biliary calculi complicated with diabetes after laparoscopic cholecystectomy (LC).
Methods A total of 126 patients with LC were divided into diabetes group (41 cases) and non-diabetes group (85 cases). The ratio of lactulose to mannitol (L/M) in urine was detected by high-performance liquid chromatography, and the levels of urinary intestinal fatty acid binding protein (IFABP) and serum D-lactate were measured by enzyme-linked immunosorbent assay (ELISA) before operation and on the 1^st and 3^rd day after operation.
Results The patients of two groups successfully completed the operations, no patients transferred to open surgeries. The anal exhaust time in the diabetic group was significantly longer than that in the non-diabetes group (P < 0.05). Urine L/M, serum D-lactic acid and urinary IFABP on the 1^st and 3^rd postoperative day in the diabetic group were significantly higher than those before treatment and non-diabetic group (P < 0.05).
Conclusion Intestinal barrier dysfunction will aggravate in patients with biliary calculi complicated with diabetes undergoing LC surgery. Preoperative control of blood glucose levels may reduce the severity of intestinal damage.
- cholecystectomy,
- diabetes,
- laparoscopic cholecystectomy,
- intestinal barrier function

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Effect of laparoscopic cholecystectomy on intestinal barrier function in patients with cholelithiasis complicated with diabetes mellitus

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