Research advances in correlation between absent in melanoma 2 and psoriasis

LIANG Daiwen; WANG Liya; ZHU Xiaofang

doi:10.7619/jcmp.20200520

Journal of Clinical Medicine in Practice > 2021 > 25(2): 122-124. > DOI: 10.7619/jcmp.20200520

LIANG Daiwen, WANG Liya, ZHU Xiaofang. Research advances in correlation between absent in melanoma 2 and psoriasis[J]. Journal of Clinical Medicine in Practice, 2021, 25(2): 122-124. DOI: 10.7619/jcmp.20200520

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Research advances in correlation between absent in melanoma 2 and psoriasis

1.
Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011
2.
Medical College, Yangzhou University, Yangzhou, Jiangsu, 225001
3.
Department of Dermatology, Clinical Medical College of Yangzhou University, Yangzhou, Jiangsu, 225001

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Received Date: August 12, 2020
Available Online: January 26, 2021
Published Date: January 27, 2021

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Abstract

Abstract

Psoriasis is chronic autoimmune inflammatory skin disease and its pathogenesis has not been fully understood. Absent in melanoma 2 (AIM2) is a sensor involved in innate immune response, can recognize double stranded deoxyribonucleic acid (dsDNA) and further assemble them into AIM2 inflammosome. AIM2 inflammasome is a protein complex, while inappropriate recognition of cytoplasmic self-DNA by AIM2 contributes to the development of psoriasis, atopic dermatitis, arthritis and other autoimmune as well as inflammatory diseases. Therefore, inhibition of AIM2 inflammasome activation is expected to be a new therapeutic target for psoriasis. This article reviewed the mechanism of AIM2 in psoriasis and the evidence of AIM2 inflammasome involving in the pathogenesis of experimental psoriasis model.
- bsent in melanoma 2,
- psoriasis,
- pyroptosis,
- inflammasone

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