Effect of Qingfei Tongfu Decoction on the lung function, score of TCM syndrome and levels of inflammatory factors in patients with severe pneumonia differentiated as syndrome of obstruction of phlegm-heat in lung

MAO Xue; ZHAO Xin

doi:10.7619/jcmp.201916014

Journal of Clinical Medicine in Practice > 2019 > 23(16): 51-53, 57. > DOI: 10.7619/jcmp.201916014

MAO Xue, ZHAO Xin. Effect of Qingfei Tongfu Decoction on the lung function, score of TCM syndrome and levels of inflammatory factors in patients with severe pneumonia differentiated as syndrome of obstruction of phlegm-heat in lung[J]. Journal of Clinical Medicine in Practice, 2019, 23(16): 51-53, 57. DOI: 10.7619/jcmp.201916014

Citation:

PDF (672 KB)

Effect of Qingfei Tongfu Decoction on the lung function, score of TCM syndrome and levels of inflammatory factors in patients with severe pneumonia differentiated as syndrome of obstruction of phlegm-heat in lung

MAO Xue¹,
ZHAO Xin^2,

1.
Yan′an Hospital of Traditional Chinese Medicine, Yan′an, Shaanxi, 716200
2.
Department of Pharmacy, Yichuan County Hospital of Traditional Chinese Medicine, Yan′an, Shaanxi, 716200

More Information

Received Date: May 12, 2019
Accepted Date: August 12, 2019
Available Online: February 28, 2021
Published Date: August 27, 2019

Graphical Abstract

Abstract

Abstract

Objective To explore the effect of Qingfei Tongfu Decoction on the lung function, score of TCM syndrome and levels of inflammatory factors in patients with severe pneumonia differentiated as syndrome of obstruction of phlegm-heat in lung.
Methods Totally 80 patients with severe pneumonia differentiated as syndrome of obstruction of phlegm-heat in lung were randomly divided into control group and observation group, with 40 cases in each group. The control group was treated with conventional treatment, while the observation group was treated with Qingfei Tongfu Decoction on the basis of conventional treatment. The scores of TCM syndromes (fever, cough, shortness of breath, etc.), lung function indexes[forced vital capacity (FVC), forced expiratory volume in one second (FEV₁), maximum ventilation volume (MVV) per minute] and inflammatory factors [white blood cell count (WBC), C reactive protein (CRP), interleukin-6 (IL-6)] before and after treatment were compared between the two groups.
Results After 2 weeks of treatment, the scores of fever, cough and shortness of breath in both groups were significantly lower than those before treatment (P < 0.05), and the observation group was significantly lower than the control group (P < 0.05). After 2 weeks of treatment, FVC, FEV₁ and MVV of the two groups were significantly higher than those before treatment (P < 0.05), and the observation group was significantly higher than the control group (P < 0.05). After 2 weeks of treatment, WBC, CRP and IL-6 levels in both groups were significantly lower than those before treatment (P < 0.05), and the observation group was significantly lower than the control group (P < 0.05).
Conclusion Qingfei Tongfu Decoction is effective in treatment of patients with severe pneumonia differentiated as syndrome of obstruction of phlegm-heat in lung, which can improve the symptoms of patients, inhibit inflammatory response, enhance lung function, and promote rehabilitation of patients.

FullText(HTML)

References (8)

References

[1]	1] 冯原, 陈斯宁, 周继红, 等. 清肺化痰通腑方治疗痰热壅肺证肺胀临床研究[J]. 深圳中西医结合杂志, 2016, 26(24): 37-38. https://www.cnki.com.cn/Article/CJFDTOTAL-SZZX201624019.htm
[2]	Park J, Lee J S, Rhee C, et al. Effect of Indacaterol on Cough and Phlegm in Chronic Obstructive Pulmonary Disease Patients: A Meta-Analysis of Five Randomized Controlled Trials[J]. Journal of Korean Medical Science, 2015, 30(10): 1453-1458. doi: 10.3346/jkms.2015.30.10.1453
[3]	中国医师协会急诊医师分会. 中国急诊重症肺炎临床实践专家共识[J]. 中国急救医学, 2016, 36(2): 97-107.
[4]	梁文杰, 方朝义, 沈莉, 等. 实验诊断学在现行《中医病证诊断疗效标准》中的应用分析[J]. 河北中医药学报, 2011, 26(2): 47-48. https://www.cnki.com.cn/Article/CJFDTOTAL-HZYX201102035.htm
[5]	Weigang J, Ying Q, Wei W, et al. Add-on effect of Qinbei Qingfei Yiqi granules for ventilator-associated pneumonia in intensive care units: a randomized controlled trial[J]. Journal of Traditional Chinese Medicine, 2017, 37(2): 165-170. doi: 10.1016/S0254-6272(17)30040-7
[6]	崔英海, 姚明, 李丁蕾. 自拟宣壅清肺汤辅助西医治疗重症肺炎(痰热壅肺证)临床观察[J]. 中国中医急症, 2017, 26(1): 155-157. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJZ201701056.htm
[7]	邹外龙, 刘仲楠, 周绍文. 清肺定喘泻热法对呼吸机相关性重症肺炎(痰热壅肺证)肺功能、中医证候积分和炎症因子的影响[J]. 中国中医急症, 2016, 25(9): 1809-1811. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJZ201609057.htm
[8]	郑彩莲, 孙建光, 张素蕊, 等. 清肺通腑汤治疗重症肺炎痰热壅肺证临床疗效及对炎症因子的影响[J]. 中国中医急症, 2017, 26(9): 1643-1645. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYJZ201709044.htm

Cited By

Get Citation

PDF

XML

Article views (293) PDF downloads (6)

Turn off MathJax

Article Contents

Abstract

References

Effect of Qingfei Tongfu Decoction on the lung function, score of TCM syndrome and levels of inflammatory factors in patients with severe pneumonia differentiated as syndrome of obstruction of phlegm-heat in lung

Abstract

References

Catalog

Export File

Citation

Format

Content