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摘要: 急性颅脑损伤为神经外科常见病,重型颅脑损伤患者的死亡率较高.急性颅脑损伤后神经细胞的原发性损害将很快导致神经细胞缺氧、脑水肿等损害.研究[1]发现,颅脑损伤后脑组织细胞内Mg2+下降为造成继发性脑损害的重要因素.Mg2+能通过多种途径减轻颅脑损伤后的脑损害,提高患者生存率,改善预后[2].本研究通过研究急性重型颅脑损伤患者血清中Mg2+含量变化对神经元特异性烯醇化酶(NSE)、S100B蛋白(S100B protein)和格拉斯哥昏迷评分(GCS)的影响,探讨其对重型颅脑损伤患者继发性脑损害的影响.
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