不同剂量脑预防照射对局限期小细胞肺癌患者的临床观察

郑晓丽; 杨成梁; 葛红

不同剂量脑预防照射对局限期小细胞肺癌患者的临床观察

1.
郑州大学基础医学院,河南郑州,450001;
2.
河南省肿瘤医院,郑州大学附属肿瘤医院放疗科,河南郑州,450003

基金项目: 中国高校医学期刊临床专项资金

详细信息

中图分类号: R734.2
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出版历程
- 发布日期: 2013-01-15

Clinical observation of different doses of brain prophylactic irradiation for limited stage small cell lung cancer

摘要

摘要: 目的观察局限期小细胞肺癌不同剂量预防性全脑照射(PCI)对降低脑转移和生存率的影响.方法将本院收治的84例局限期小细胞肺癌患者随机分组,根据患者治疗要求分为标准PCI剂量组、较高PCI剂量组和对照组.观察患者两年脑转移发生率、总生存率以及放射性脑损伤引发的不良反应.结果标准剂量PCI组与较高剂量PCI组的2年脑转移发生率经比较,差异无统计学差异.发生脑转移患者与未发生脑转移患者的中位生存时间分别为17.6个月和47.4个月;标准剂量组的1年和3年生存率高于较高剂量组,但差异不明显.结论局限期小细胞肺癌术后化疗或放化疗后预防性脑照射可以降低脑转移率,25 Gy的PCI仍然应该是局限期小细胞肺癌的标准治疗剂量.
- 小细胞肺癌 /
- 局限期 /
- 预防性全脑照射 /
- 脑转移 /
- 生存率

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参考文献(8)

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