肝癌、肝硬化患者AFP、SF、β_2-MG、HA联合检测结果分析

施根林; 何海明; 刘金波

肝癌、肝硬化患者AFP、SF、β_2-MG、HA联合检测结果分析

ANALYSIS OF COMBINED DETECTIVE RESUITS OF α-FETOPROTEIN, FERRITIN, β_2-MICROGLOBULIN AND HYALURONIC ACID IN SERUM OF PATIENTS WITH PRIMARY HEPATOCELLULAR CARCINOMA AND PATIENTS WITH LIVER CIRRHOSIS

摘要

摘要: 采用放射免疫法（RIA）对42例原发性肝癌（PHC）、31例肝硬化（LC）及28例正常人的血清甲胎蛋白（AFP）、铁蛋白（SF）、β2—微球蛋白（β2—MG）和透明质酸（HA）进行联合检测．结果，PHC和LC组SF、β2—MG、HA单项检测的阳性率分别为71．4％和25．8％（P＜0．01）、50．0％和38．7％（P＜0．05）、83．3％和83．8％（P＞0．05）；SFβ2—MG、HA含量在PHC和LC中重叠比例较高，对PHC、LC诊断无特异性，SF、HA含量变化投度对PHC和LC鉴别诊断具有一定参考价值。AFP、SF、β2—MG、HA四项指标联合检测，以SF、β2—MG、HA三项中至少两项阳性作为PHC诊断依据．其敏感性为81．0％，特异性为67．7％，可靠性75．3％，对AFP阴性或低浓度阳性PHC的诊断阳性单为82．6％；联合检测AFP，对PHC的诊断敏感性为90．5％，特异性为87．0％，可靠性为89．2％，大大提高了PHC的诊断率。

Abstract: Serum concentration of α - fetoprotein (AFP), ferritin (SF), β2- microglobulin (β2 -MG) and hyaluronic acid(HA) were determined by radioimmunoassay(RIA) in 42 potients with primaryhepatocellular carcinoma (PHC), 31 liver cirrhosis(LC)and 28 normal persons. The results showed that thepositive rates of determining each of SF, β2 -MG, HA in PHC and LC were 71. 4% and 25. 8% (P0.01 ) ; 50. 0% and 38. 7% (P0. 05); 83. 3% and 83. 8% (P0. 05). The measurement of SF,β2-MG,HA haven't specificity in diagnosing PHC and LC because they are overlapping high. The change rang ofSF and HA contents may be useful in the discrimination diagnosis of PHC and LC. Diagnosing PHC de-pendedon two of SF,β2-MG and HA at least had a sensitivity of 81. 0% and a specificity of 67. 7 % and areliability of 75. 3%,and had a positive rate of 82. 6 N in PHC with AFP negative or lower levels- When it were combined AFP,the diagnosis accuracy of PHC may rise. It had a sensitivity of 90. 5 % and a specificity of 87. 0% and reliability of 89. 2%.,

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