Objective To investigate the impact of music therapy combined with resistance exercise on post-dialysis fatigue status, sleep quality, and depression in patients undergoing maintenance hemodialysis (MHD).

Methods A total of 96 MHD patients were selected and divided into control group(48 cases) and observation group(48 cases) using a random number table method. The control group received routine dialysis care, while the observation group was given music therapy combined with resistance exercise based on routine care. After six months of intervention, changes in fatigue status, sleep quality, psychological depression status, and dialysis adequacy urea clearance index (Kt/V), urea reduction ratio (URR) were compared between the two groups.

Results Post-intervention, the total score of the Revised Piper Fatigue Scale (RPFS) in the observation group was lower than that in the control group (2.31±0.77) versus (3.48±0.93), P < 0.05. The Pittsburgh Sleep Quality Index (PSQI) score in the observation group was lower than that in the control group (7.26±2.56) versus (9.94±3.27), P < 0.05. The scores for the two subscales of the Hospital Anxiety and Depression Scale (HADS) in the observation group were (3.18±1.02) and (3.96±1.23), which were lower than (4.53±1.47) and (5.77±2.07)in the control group (P < 0.05). Additionally, the Kt/V and URR values in the observation group were (1.38±0.25) and (0.74±0.11)%, respectively, which were higher than (1.26±0.28) and (0.69±0.12)% in the control group(P < 0.05).

Conclusion Music therapy combined with resistance exercise can relieve post-dialysis fatigue, improve sleep quality, regulate psychological status, and enhance dialysis adequacy in MHD patients.