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血清淀粉样蛋白A、嗜酸性粒细胞趋化因子、正五聚蛋白3水平与肺炎支原体肺炎患儿肺功能指标、肺炎支原体DNA水平及预后的关系

Relationships of serum amyloid A, eotaxin and pentraxin 3 levels with lung function indexes, Mycoplasma pneumoniae DNA level and prognosis in children with Mycoplasma pneumoniae pneumonia

    摘要
  • 摘要:
    目的 探讨血清淀粉样蛋白A(SAA)、嗜酸性粒细胞趋化因子(Eotaxin)、正五聚蛋白3(PTX3)水平与肺炎支原体肺炎(MPP)患儿肺炎支原体DNA(MP-DNA)水平、肺功能及预后的关系。
    方法 选取本院163例MPP患儿为MPP组，根据预后情况分为预后良好组(n=109)和预后不良组(n=54); 另选取124例同期健康体检儿童为对照组。检测患儿SAA、Eotaxin、PTX3水平。采用多因素Logistic回归分析探讨MPP患儿预后不良的危险因素。
    结果 与对照组比较, MPP组SAA、Eotaxin、PTX3水平以及MP-DNA阳性率升高，差异有统计学意义(P < 0.01); MPP组呼气峰流速(PEF)、第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、达峰时间比(tPTEF/TE)、潮气量均低于对照组，差异有统计学意义(P < 0.01)。与预后良好组比较，预后不良组MP-DNA水平以及SAA、Eotaxin、PTX3水平升高, PEF、FEV1、FVC、tPTEF/TE、潮气量降低，差异均有统计学意义(P < 0.01)。多因素Logistic回归分析显示，高MP-DNA水平，高SAA、Eotaxin、PTX3水平，低PEF、FEV1、FVC、tPTEF/TE水平以及低潮气量是MPP患儿预后不良的危险因素(P < 0.01)。MPP患儿SAA、PTX3、Eotaxin水平与其MP-DNA水平呈正相关，与肺功能指标均呈负相关(P < 0.05)。
    结论 SAA、PTX3、Eotaxin水平与MPP患儿MP-DNA水平呈正相关，与肺功能指标呈负相关。SAA、PTX3、Eotaxin水平可用于评估MPP患儿预后。

     

    Abstract:
    Objective To investigate the relationships of serum amyloid A (SAA), eotaxin and pentraxin 3 (PTX3) levels with Mycoplasma pneumoniae DNA (MP-DNA) level, lung function and prognosis in children with Mycoplasma pneumoniae pneumonia (MPP).
    Methods A total of 163 children with MPP were enrolled in MPP group and divided into good prognosis group (n=109) and poor prognosis group (n=54) based on prognosis; another 124 healthy children with physical examinations in the same period were included as control group. Levels of serum SAA, eotaxin and PTX3 were measured in the children. Multivariable Logistic regression analysis was conducted to explore risk factors for poor prognosis in children with MPP.
    Results Compared with the control group, the MPP group had significantly increased levels of SAA, eotaxin, PTX3 and MP-DNA positivity (P < 0.01); the MPP group also had significantly lower values of peak expiratory flow (PEF), forced expiratory volume in the first second (FEV1), forced vital capacity (FVC), tidal expiratory flow time to total expiratory time (tPTEF/TE), and tidal volume compared with the control group (P < 0.01). Compared with the good prognosis group, the poor prognosis group had significantly increased MP-DNA level, SAA, eotaxin and PTX3 levels, as well as decreased values of PEF, FEV1, FVC, tPTEF/TE and tidal volume (P < 0.01). Multivariable Logistic regression analysis showed that high MP-DNA level, high SAA, eotaxin and PTX3 levels, low values of PEF, FEV1, FVC, tPTEF/TE and tidal volume were risk factors for poor prognosis in children with MPP (P < 0.01). The SAA, PTX3 and eotaxin levels in children with MPP were positively correlated with their MP-DNA level and negatively correlated with lung function indicators (P < 0.05).
    Conclusion SAA, PTX3 and eotaxin levels are positively correlated with MP-DNA level and negatively correlated with lung function indicators in children with MPP. SAA, PTX3 and eotaxin levels can be used to assess the prognosis of children with MPP.

     

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