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进展期寻常型银屑病患者血清可溶性血红蛋白清道夫受体、白细胞介素-38水平变化及临床意义

Changes and clinical significance of serum levels of soluble CD163 and interleukin-38 in patients with advanced plaque psoriasis

    摘要
  • 摘要:
    目的 分析进展期寻常型银屑病患者血清可溶性血红蛋白清道夫受体(sCD163)、白细胞介素-38(IL-38)的水平变化及临床意义。
    方法 选取80例寻常型银屑病(PsV)患者为研究对象(PsV组)，根据银屑病面积与严重性指数(PASI)评分将患者分为轻度PsV组30例、中度PsV组21例和重度PsV组29例。选取同期80例健康体检者为对照组。采用酶联免疫吸附法(ELISA)检测研究对象血清sCD163、IL-38水平。采用Spearman相关性分析法分析血清sCD163、IL-38表达水平与PsV患者病情严重程度的相关性。
    结果 PsV组sCD163水平高于对照组, IL-38水平低于对照组，差异有统计学意义(P < 0.001)。PsV患者血清sCD163水平随疾病严重程度的增加而升高，差异有统计学意义(F=10.207, P < 0.001)。PsV患者血清IL-38水平随疾病严重程度的增加而降低，差异有统计学意义(F=55.116, P < 0.001)。PsV患者血清sCD163表达水平与PASI评分呈正相关(r=0.549, P=0.013); PsV患者血清IL-38表达水平与PASI评分呈负相关(r=-0.601, P=0.007)。受试者工作特征(ROC)曲线分析显示, sCD163、IL-38诊断中重度PsV的曲线下面积(AUC)分别为0.84、0.86, 两者联合检测的AUC为0.94, 大于其单独检测结果(Z联合-sCD163=2.021, Z联合-IL-38=2.331, P < 0.05)。
    结论 PsV患者血清sCD163水平显著升高, IL-38水平显著降低，其均与PsV疾病严重程度密切相关。sCD163、IL-38联合检测对中重度PsV的诊断价值较高。

     

    Abstract:
    Objective To analyze the changes and clinical significance of serum levels of soluble CD163 (sCD163) and interleukin-38 (IL-38) in patients with plaque psoriasis (PsV).
    Methods Eighty patients with PsV were selected as study subjects (PsV group), and divided into mild PsV group (n=30), moderate PsV group (n=21), and severe PsV group (n=29) based on the Psoriasis Area and Severity Index (PASI) score. A total of 80 healthy subjects were selected as control group. Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels of sCD163 and IL-38 in all participants. Spearman's correlation analysis was employed to assess the correlations of serum levels of sCD163 and IL-38 with the severity of PsV.
    Results The level of sCD163 in the PsV group was significantly higher, and the level of IL-38 was significantly lower than that in the control group (P < 0.001). Serum sCD163 levels in PsV patients increased significantly with the increase of disease severity (F=10.207, P < 0.001). Serum IL-38 levels in PsV patients decreased significantly with the increase of disease severity (F=55.116, P < 0.001). The expression level of sCD163 in PsV patients was positively correlated with PASI score (r=0.549, P=0.013); the expression level of IL-38 in PsV patients was negatively correlated with PASI score (r=-0.601, P=0.007). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of sCD163 and IL-38 in the diagnosis of moderate and severe PsV were 0.835 and 0.856, respectively, and the AUC of the combined detection of SCD163 and IL-38 was 0.935, which was higher than that of the single detection(Zcombined-sCD163=2.021, Zcombined-IL-38=2.331, P < 0.05).
    Conclusion Serum sCD163 levels are significantly elevated, while IL-38 levels are significantly reduced in PsV patients, both closely correlating with disease severity. The combined detection of sCD163 and IL-38 has high diagnostic value for moderate to severe PsV.

     

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