Objective To explore the intervention effect of the "5E" rehabilitation nursing model (Education, Encouragement, Evaluation, Exercise, and Employment) for patients with primary aldosteronism (PA).

Methods A total of 120 patients diagnosed as PA in the Cardiology Department of the Third People's Hospital of Qingdao from January 2022 to June 2024 were randomly divided into control group (n=60) and observation group (n=60). The control group received routine nursing intervention, while the observation group received the "5E" rehabilitation nursing intervention. Blood test indicators, clinical manifestations (blood pressure, fatigue level), score of quality of life, and nursing satisfaction rate were compared between the two groups.

Results After intervention, blood sodium, plasma aldosterone, blood creatinine, urea nitrogen, uric acid, systolic blood pressure, diastolic blood pressure, and scores of fatigue degree in the observation group were significantly lower than those in the control group, while blood potassium level and score of quality of life were significantly higher than those in the control group (P < 0.05). The nursing satisfaction rate in the observation group was 96.67%, which was significantly higher than 80.00% in the control group (P < 0.05).

Conclusion Implementation of the "5E" rehabilitation nursing intervention during hospitalization for PA patients can improve their blood indicators and clinical symptoms, alleviate the severity of the disease, and enhance their qualities of life.