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三阴性乳腺癌多模态超声参数与增殖细胞核抗原、细胞角蛋白5/6的相关性分析

Correlations of multimodal ultrasound parameters with Ki-67 and cytokeratin 5/6 in triple-negative breast cancer

    摘要
  • 摘要:
    目的 分析三阴性乳腺癌(TNBC)多模态超声参数与增殖细胞核抗原(Ki-67)、细胞角蛋白5/6(CK5/6)的相关性。
    方法 回顾性选取2017年1月—2023年12月在江苏大学附属句容医院、江苏省人民医院就诊的212例乳腺癌患者为研究对象，并分为TNBC组(n=95)和非TNBC组(n=117)。采用免疫组化法检测2组患者Ki-67、CK5/6表达; 分析超声参数与Ki-67、CK5/6的相关性。
    结果 TNBC组CK5/6、Ki-67阳性率分别为69.47%(66/95)、75.79%(72/95), 非TNBC组CK5/6、Ki-67阳性率分别为23.93%(28/117)、14.53%(17/117)，差异有统计学意义(P < 0.05)。TNBC组中, CK5/6高水平与低水平患者在病灶最大径、形态、边界、纵横比、有无钙化灶、肿块后方回声情况、有无淋巴结转移及远处转移方面比较，差异有统计学意义(P < 0.05); CK5/6高水平与低水平患者在分布情况、增强模式、灌注缺损方面比较，差异有统计学意义(P < 0.05)。Ki-67高水平与低水平患者在病灶最大径、形态、边界、纵横比、有无钙化灶、肿块后方回声情况、有无淋巴结转移及远处转移方面比较，差异有统计学意义(P < 0.05); Ki-67高水平与低水平患者在增强后范围、分布情况、增强模式方面比较，差异有统计学意义(P < 0.05)。多因素分析
    结果 表明，边界清楚、钙化灶、增强后范围是CK5/6阳性的独立影响因素(P < 0.05), 增强模式、增强后范围是Ki-67阳性的独立影响因素(P < 0.05)。
    结论 Ki-67、CK5/6在TNBC患者中阳性表达率更高，多模态超声参数与Ki-67、CK5/6具有一定相关性。

     

    Abstract:
    Objective To analyze the correlations of multimodal ultrasound parameters with Ki-67 and cytokeratin 5/6 (CK5/6) in triple-negative breast cancer (TNBC).
    Methods A retrospective analysis was conducted on 212 breast cancer patients in Jurong Hospital Affiliated to Jiangsu University and Jiangsu Provincial People′s Hospital from January 2017 to December 2023. The patients were divided into TNBC group (n=95) and non-TNBC group (n=117). Immunohistochemical staining was used to detect the expression of Ki-67 and CK5/6 in both groups, and the correlations of ultrasound parameters with Ki-67 and CK5/6 were analyzed.
    Results In the TNBC group, the positive rates of CK5/6 and Ki-67 were 69.47% (66/95) and 75.79% (72/95) respectively, while in the non-TNBC group, the positive rates were 23.93% (28/117) and 14.53% (17/117) respectively, with significant between-group differences (P < 0.05). In the TNBC group, patients with high and low level of CK5/6 showed significant differences in maximum lesion diameter, morphology, margin, aspect ratio, presence of calcifications, posterior acoustic pattern, lymph node metastasis, and distant metastasis (P < 0.05); similarly, patients with high and low level of CK5/6 demonstrated significant differences in distribution, enhancement pattern, and perfusion defects (P < 0.05); patients with high and low level of Ki-67 also exhibited significant differences in maximum lesion diameter, morphology, margin, aspect ratio, presence of calcifications, posterior acoustic pattern, lymph node metastasis, and distant metastasis (P < 0.05); additionally, patients with high and low level of Ki-67 showed significant differences in the enhanced range, distribution, and enhancement pattern (P < 0.05). Multivariate analysis revealed that clear margin, calcifications, and enhanced range were independent influencing factors for CK5/6 positivity (P < 0.05), while enhancement pattern and enhanced range were independent influencing factors for Ki-67 positivity (P < 0.05).
    Conclusion Ki-67 and CK5/6 have higher positive expression rates in TNBC patients, and multimodal ultrasound parameters are correlated with Ki-67 and CK5/6.

     

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