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血清hsa_circ_0002348、hsa_circ_0001740水平与妊娠期高血压严重程度的相关性研究

Correlations of serum hsa_circ_0002348 and hsa_circ_0001740 levels with severity of gestational hypertension

    摘要
  • 摘要:
    目的 探讨血清hsa_circ_0002348、hsa_circ_0001740水平与妊娠期高血压严重程度的相关性。
    方法 选取本院2018年1月—2023年1月收治的169例妊娠期高血压患者为研究组，按病情严重程度分为轻度子痫前期组(n=82)、重度子痫前期组(n=47)、子痫组(n=40)。另选取同期在本院孕检健康的169例孕妇为对照组。采用实时荧光定量PCR(qRT-PCR)检测血清hsa_circ_0002348、hsa_circ_0001740的相对表达量。分析血清hsa_circ_0002348、hsa_circ_0001740水平与疾病严重程度的关系。绘制受试者工作特征(ROC)曲线，分析血清hsa_circ_0002348、hsa_circ_0001740水平诊断妊娠期发生子痫的价值。
    结果 对照组、轻度子痫前期组、重度子痫前期组、子痫组患者收缩压、舒张压均升高，差异有统计学意义(P < 0.01)。子痫组、重度子痫前期组、轻度子痫前期组、对照组血清hsa_circ_0002348水平依次呈降低趋势, hsa_circ_0001740依次呈升高趋势，组间两两比较差异有统计学意义(P < 0.01)。血清hsa_circ_0002348联合hsa_circ_0001740诊断妊娠期发生子痫的曲线下面积(AUC)高于各自单独诊断的AUC(Zhsa_circ_0002348∶hsa_circ_0002348+hsa_circ_0001740=4.677, P < 0.001; Zhsa_circ_0001740∶hsa_circ_0002348+hsa_circ_0001740=3.579, P < 0.001)。Spearman法分析结果显示，血清hsa_circ_0002348与疾病严重程度呈正相关(rs=0.751, P < 0.05), hsa_circ_0001740与疾病严重程度呈负相关(rs=-0.638, P < 0.05)。多因素Logistic回归分析显示收缩压(OR=2.652)、舒张压(OR=3.247)、hsa_circ_0002348(OR=2.365)和hsa_circ_0001740(OR=0.325)是疾病严重程度的影响因素(P < 0.05)。
    结论 随着妊娠期高血压严重程度加重，血清hsa_circ_0002348水平显著升高，hsa_circ_0001740水平显著降低，二者与妊娠期高血压严重程度具有一定的相关性。

     

    Abstract:
    Objective To investigate the correlations of serum hsa_circ_0002348 and hsa_circ_0001740 levels with the severity of gestational hypertension.
    Methods A total of 169 patients with gestational hypertension in the hospital from January 2018 to January 2023 were selected as study group, and they were divided into mild preeclampsia group (n=82), severe preeclampsia group (n=47), and eclampsia group (n=40) according to the severity of the disease. Another 169 healthy pregnant women with antenatal examination in the same period were selected as control group. Real-time fluorescent quantitative PCR (qRT-PCR) was used to detect the relative expression levels of serum hsa_circ_0002348 and hsa_circ_0001740. The correlations of serum hsa_circ_0002348 and hsa_circ_0001740 levels with the severity of the disease were analyzed. Receiver operating characteristic (ROC) curve was plotted to analyze the values of serum hsa_circ_0002348 and hsa_circ_0001740 levels in diagnosing eclampsia during pregnancy.
    Results The systolic and diastolic blood pressures of the control group, mild preeclampsia group, severe preeclampsia group, and eclampsia group were all significantly increased (P < 0.01). The level of serum hsa_circ_0002348 in the eclampsia group, severe preeclampsia group, mild preeclampsia group, and control group showed a decreasing trend in sequence, while the level of hsa_circ_0001740 showed an increasing trend in sequence, with significant between-group differences (P < 0.01). The area under the curve (AUC) for diagnosing eclampsia during pregnancy by the combination of serum hsa_circ_0002348 and hsa_circ_0001740 was significantly higher than the AUC for diagnosis by each individual index (Zhsa_circ_0002348: hsa_circ_0002348+hsa_circ_0001740=4.677, P < 0.001; Zhsa_circ_0001740: hsa_circ_0002348+hsa_circ_0001740=3.579, P < 0.001). Spearman analysis showed that serum hsa_circ_0002348 was positively correlated with the severity of the disease (rs=0.751, P < 0.05), while hsa_circ_0001740 was negatively correlated with the severity of the disease (rs=-50.638, P < 0.05). Multivariate Logistic regression analysis showed that systolic blood pressure (OR=2.652), diastolic blood pressure (OR=3.247), hsa_circ_0002348 (OR=2.365), and hsa_circ_0001740 (OR=0.325) were influencing factors of severity of the disease (P < 0.05).
    Conclusion As the severity of gestational hypertension increases, the serum hsa_circ_0002348 level increases significantly, while the hsa_circ_0001740 level decreases significantly. Two indexes are correlated with the severity of gestational hypertension.

     

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