Abstract: Diabetic retinopathy is one of the most common and specific chronic complications of diabetes mellitus, which is a serious and irreversible progressive blinding eye disease. The visual impairment caused by the progression of the disease and the economic burden caused by the treatment of the disease lead to psychological problems such as anxiety and depression, affecting the quality of life and physical and mental health, and increasing the burden on the family and society. This article reviewed the current status of epidemiological research on DR, discussed the correlation of DR with anxiety and depression and its influencing factors, analyzed the research progress of evaluation and intervention methods, aiming to provide assistance for improving patients' treatment compliance and quality of life.