重型颅脑损伤患者术后继发性脑积水的危险因素分析及列线图风险模型构建

Risk factors for postoperative secondary hydrocephalus in patients with severe craniocerebral injury and construction of nomogram risk model

  • 摘要:
    目的 探讨重型颅脑损伤患者术后继发性脑积水的危险因素, 并构建列线图预测模型。
    方法 选取360例重型颅脑损伤患者作为研究对象,并根据术后继发性脑积水发生情况分为脑积水组(n=34)和非脑积水组(n=326)。采用Logistic回归分析法筛选术后继发性脑积水的危险因素。基于筛选出的危险因素构建重型颅脑损伤患者术后继发性脑积水的列线图模型,并验证其预测效能。
    结果 360例患者中,术后发生继发性脑积水34例,继发性脑积水发生率为9.44%(34/360)。Logistic回归分析结果显示,颅内感染、脑室出血、中线移位程度≥12 mm、术前格拉斯哥昏迷评分法(GCS)评分3~5分、去骨瓣减压、硬膜敞开是重型颅脑损伤患者术后继发性脑积水的独立危险因素(P < 0.05)。基于上述危险因素构建的列线图模型的模型一致性指数为0.874, 曲线下面积为0.831。
    结论 本研究基于颅内感染、脑室出血、中线移位程度、术前GCS评分、去骨瓣减压及硬膜敞开因素构建的列线图模型,能够有效预测重型颅脑损伤患者术后继发性脑积水的风险,对早期防治具有临床指导意义。

     

    Abstract:
    Objective To explore the risk factors for postoperative secondary hydrocephalus in patients with severe craniocerebral injury and construct a nomogram prediction model.
    Methods A total of 360 patients with severe craniocerebral injury were selected as the study subjects, and divided into hydrocephalus group (n=34) and non-hydrocephalus group (n=326) based on the occurrence of postoperative secondary hydrocephalus. Logistic regression analysis was used to screen for risk factors of postoperative secondary hydrocephalus. A nomogram model for predicting postoperative secondary hydrocephalus in patients with severe craniocerebral injury was constructed based on the identified risk factors, and its predictive performance was validated.
    Results Among the 360 patients, 34 developed secondary hydrocephalus after surgery, with an incidence rate of 9.44% (34/360). Logistic regression analysis revealed that intracranial infection, ventricular hemorrhage, midline shift ≥12 mm, preoperative Glasgow Coma Scale (GCS) score of 3 to 5, decompressive craniectomy and dura mater opening were independent risk factors for postoperative secondary hydrocephalus in patients with severe traumatic brain injury (P < 0.05). The concordance index of the nomogram model constructed based on these risk factors was 0.874, and the area under the curve was 0.831.
    Conclusion The nomogram model constructed in this study based on factors such as intracranial infection, ventricular hemorrhage, midline shift, preoperative GCS score, decompressive craniectomy and dura mater opening, effectively predicts risk of postoperative secondary hydrocephalus in patients with severe traumatic brain injury. This model has clinical significance for early prevention and treatment.

     

/

返回文章
返回