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支气管哮喘患儿急性期血清双特异性磷酸酶1、可溶性分化簇93与病情严重程度、肺功能和气道炎症的相关性研究

Correlations of serum dual-specific phosphatase 1 and soluble cluster of differentiation 93 with severity of disease, lung function and airway inflammation in children with acute-phase bronchial asthma

    摘要
  • 摘要:
    目的 探讨支气管哮喘(BA)患儿急性期血清双特异性磷酸酶1(DUSP1)、可溶性分化簇93(sCD93)与病情严重程度、肺功能和气道炎症的相关性。
    方法 选取2021年1月—2023年1月榆林市星元医院收治的急性期BA患儿100例(急性期组)、缓解期BA患儿100例(缓解期组)、健康儿童100例(对照组), 根据病情严重程度将急性期组又分为轻度亚组47例、中度亚组36例、重度亚组17例。检测各组血清DUSP1、sCD93水平和肺功能指标峰值呼气流速(PEF)、第1秒用力呼气容积占预计值百分比(FEV1%pred)、气道炎症指标嗜酸粒细胞(EOS)计数、呼出气一氧化氮(FeNO)。采用Pearson法分析BA急性期患儿血清DUSP1、sCD93水平与PEF、FEV1%pred、EOS、FeNO的相关性。
    结果 急性期组血清DUSP1水平和PEF、FEV1%pred低于缓解期组、对照组, sCD93水平和EOS计数、FeNO高于缓解期组、对照组，差异有统计学意义(P < 0.01)。重度亚组血清DUSP1水平和PEF、FEV1%pred低于中度亚组、轻度亚组, sCD93水平和EOS计数、FeNO高于中度亚组、轻度亚组，差异有统计学意义(P < 0.01)。BA急性期患儿PEF、FEV1%pred与血清DUSP1水平呈正相关，与sCD93水平呈负相关(P < 0.01); EOS计数、FeNO与血清DUSP1水平呈负相关，与sCD93水平呈正相关(P < 0.01)。
    结论 BA急性期患儿血清DUSP1水平降低和sCD93水平升高与病情加重、肺功能降低、气道炎症密切相关，或可成为BA急性期患儿治疗的新靶点。

     

    Abstract:
    Objective To investigate the correlations of serum dual-specific phosphatase 1 (DUSP1) and soluble cluster of differentiation 93 (sCD93) with severity of disease, lung function and airway inflammation in children with acute-phase bronchial asthma (BA).
    Methods A total of 100 children with acute-phase BA (acute-phase group), 100 children with remission-phase BA (remission-phase group), and 100 healthy children (control group) in the Xingyuan Hospital of Yulin from January 2021 to January 2023 were selected, and the acute-phase group was further divided into mild subgroup (n=47), moderate subgroup (n=36) and severe subgroup (n=17) according to the severity of the disease. Serum DUSP1, sCD93 levels and lung function indexes peak expiratory flow (PEF), percentage of forced expiratory volume in the first second compared to the expected value (FEV1%pred), and airway inflammation indexes eosinophil (EOS) count, fractional exhaled nitric oxide (FeNO) were measured. Pearson's method was used to analyze the correlations of serum DUSP1 and sCD93 levels with PEF, FEV1%pred, EOS and FeNO in children with acute-phase BA.
    Results The levels of serum DUSP1, PEF, and FEV1%pred in the acute-phase group were significantly lower than those in the remission-phase group and the control group, while the levels of sCD93, EOS count and FeNO were significantly higher than those in the remission-phase group and the control group (P < 0.01). The levels of serum DUSP1, PEF and FEV1%pred in the severe subgroup were significantly lower than those in the moderate and mild subgroups, while the levels of sCD93, EOS count and FeNO were significantly higher than those in the moderate and mild subgroups (P < 0.01). PEF and FEV1%pred were positively correlated with serum DUSP1 level, but negatively correlated with sCD93 level in children with acute-phase BA (P < 0.01). EOS count and FeNO were negatively correlated with serum DUSP1 level, but positively correlated with sCD93 level (P < 0.01).
    Conclusions The decreased serum DUSP1 level and increased sCD93 level in children with acute-phase BA are closely related to the aggravation of the disease, the decrease of lung function, and airway inflammation, which may become new targets for the treatment of children with acute-phase BA.

     

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