Objective To explore the compliance and withdraw factors of sublingual immunotherapy (SLIT) with dermatophagoides farinae drops in patients with allergic rhinitis (AR).

Methods A retrospective analysis was conducted in 652 AR patients with dermatophagoides farinae drops for SLIT, and the withdraw time and reasons were recorded.

Results Of the 652 patients, 516 cases were successfully followed up, and 291 dropped out halfway, with an overall compliance rate of 43.60%. Among the patients with successful follow up, those aged < 14 years old had better compliance than those aged ≥14 years old, and there was no significant difference in the withdraw rate according to factor of gender. The months with the highest withdraw rate were the fifth, the sixth and the seventh months after administration of drugs.

Conclusion The overall compliance of AR patients with SLIT is poor, and children aged < 14 years old have better compliance than those aged ≥14 years old. Strengthening patient's education, increasing the frequency of follow-up, and building an effective communication platform can help improve patient's compliance.