Abstract: Objective To explore the effect of community-participated intervention in preventing mother-to-child transmission of syphilis. Methods The effect of community-participated intervention in the whole process health management of syphilis pregnant women and newborns was analyzed. Results After health management intervention implemented by community medical staffs, the diagnosis rate in early pregnancy and treatment rate during pregnancy in syphilis pregnant women in 2019 were significantly higher than those in 2017 and 2018(P<0.05). The incidence of neonatal adverse pregnancy outcomes in 2019 was significantly lower than that in 2017 and 2018, and the neonatal closure rate and closure rate of case with age of 3 to 6 months in infants of syphilis mothers were significantly higher than those in 2017 and 2018(P<0.05). Conclusion The establishment of community-participated management model can effectively increase the diagnosis rate and treatment rate of syphilis pregnant women, reduce the incidence of adverse pregnancy outcomes of newborns, and increase the neonatal closure rate of syphilis mothers.