The inhibiting effect of propofol on perineal pruritus caused by dexamethasone sodium phosphate
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摘要: 目的 探讨丙泊酚对地塞米松磷酸钠引起女性会阴部瘙痒的抑制作用。 方法 将60例行择期妇科手术的患者随机分为实验组和对照组,每组30例。麻醉诱导前,实验组静脉给予丙泊酚注射液,对照组静脉给予生理盐水,随后2组均静脉注射地塞米松磷酸钠。比较2组会阴部瘙痒情况、瘙痒开始和持续时间、瘙痒的视觉模拟评分(VAS)、睡眠障碍镇静评分(Ramsay评分)和不良反应发生情况。 结果 实验组瘙痒总发生率、重度瘙痒发生率均低于对照组,差异有统计学意义(P<0.05)。实验组Ramsay评分高于对照组,差异有统计学意义(P<0.05)。 结论 丙泊酚可有效抑制地塞米松磷酸钠注射液引起的会阴部瘙痒。Abstract: Objective To investigate the efficacy of propofol in inhibiting dexamethasone sodium phosphate induced perineal pruritus in women. Methods A total of sixty patients undergoing elective gynecological surgery were randomly divided into experimental group and control group, with 30 cases in each group. Before anesthesia induction, the experimental group was given propofol injection intravenously, while the control group was given saline intravenously. Subsequently, both groups received intravenous injection of dexamethasone sodium phosphate. The perineal pruritus, the onset and duration of pruritus, visual analogue scale(VAS), sleep disturbance sedation score(Ramsay score)and adverse reactions were compared between the two groups. Results The total incidence of pruritus and severe pruritus in the experimental group were significantly lower than those in the control group(P< 0.05). Ramsay score in the experimental group was significantly higher than that in the control group(P< 0.05). Conclusion Propofol can effectively inhibit the perineal pruritus caused by dexamethasone sodium phosphate injection.
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Keywords:
- propofol /
- dexamethasone /
- perineum /
- pruritus
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