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大肠腺癌组织中环状核糖核酸92400的表达及临床病理意义

颜云, 郭玉莲, 王成海

颜云, 郭玉莲, 王成海. 大肠腺癌组织中环状核糖核酸92400的表达及临床病理意义[J]. 实用临床医药杂志, 2020, 24(16): 12-14,18. DOI: 10.7619/jcmp.202016003
引用本文: 颜云, 郭玉莲, 王成海. 大肠腺癌组织中环状核糖核酸92400的表达及临床病理意义[J]. 实用临床医药杂志, 2020, 24(16): 12-14,18. DOI: 10.7619/jcmp.202016003
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YAN Yun, GUO Yulian, WANG Chenghai. Expression and clinicopathological significance of circular ribose nucleic acid 92400 in tissues of colorectal adenocarcinoma[J]. Journal of Clinical Medicine in Practice, 2020, 24(16): 12-14,18. DOI: 10.7619/jcmp.202016003
Citation: YAN Yun, GUO Yulian, WANG Chenghai. Expression and clinicopathological significance of circular ribose nucleic acid 92400 in tissues of colorectal adenocarcinoma[J]. Journal of Clinical Medicine in Practice, 2020, 24(16): 12-14,18. DOI: 10.7619/jcmp.202016003
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大肠腺癌组织中环状核糖核酸92400的表达及临床病理意义

  • 1. 扬州大学附属医院 病理科, 江苏 扬州, 225009;

  • 2. 扬州大学医学院/转化医学研究院 病理学教研室, 江苏 扬州, 225009;

  • 3. 江苏省中西医结合老年病防治重点实验室, 江苏 扬州, 225009

基金项目: 

江苏省卫生健康委医学科研项目指导性项目(Z2019046)

详细信息
    通讯作者:

    王成海,E-mail:chwang@yzu.edu.cn

  • 中图分类号: R735.3;R730.26

Expression and clinicopathological significance of circular ribose nucleic acid 92400 in tissues of colorectal adenocarcinoma

  • 1. Department of Pathology, The Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu, 225009;

  • 2. Teaching and Research Section of Pathology, Medical College of Yangzhou University, Institute of Translational Medicine, Yangzhou, Jiangsu, 225009;

  • 3. Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou, Jiangsu, 225009

摘要

    摘要
  • 摘要: 目的 探讨环状核糖核酸92400(circ-92400)在大肠腺癌组织中的表达及临床病理意义。 方法 收集102例大肠腺癌组织标本及癌旁正常肠组织标本,应用RNA原位杂交技术检测circ-92400表达情况,并分析其与病理参数的关系。 结果 circ-92400在大肠腺癌组织中呈阳性表达,阳性率为77.45%(79/102)。circ-92400阳性表达与肿瘤大小、淋巴结转移、肿瘤TNM分期、分化程度有相关性,差异有统计学意义(P<0.05)。circ-92400在大肠腺癌组织中的阳性细胞百分比为(58.00±13.00)%, 高于癌旁正常肠组织的(11.00±3.00)%, 差异有统计学意义(t=5.84, P<0.05)。 结论 大肠腺癌组织中circ-92400呈阳性表达,其阳性表达与肿瘤大小、淋巴结转移、肿瘤TNM分期、分化程度密切相关, circ-92400或可作为大肠腺癌的新的肿瘤标志物。
    Abstract: Objective To explore the expression and clinicopathological significance of circular ribose nucleic acid 92400(circ-92400)in tissues of colorectal adenocarcinoma. Methods The expression of circ-92400 was detected by RNA in situ hybridization technology in colorectal adenocarcinoma and their adjacent normal intestinal tissues of 102 cases, and the correlations between circ-92400 and pathological parameters were analyzed. Results The positive detection rate of circ-92400 was 77.45%(79/102)in tissues of colorectal adenocarcinoma. The positive expression of circ-92400 was correlated with tumor size, lymph node metastasis, TNM stage and degree of differentiation(P<0.05). The percentage value of positive circ-92400 cells in colorectal adenocarcinoma tissues was(58.00±13.00)%, which was significantly higher than(11.00±3.00)% in adjacent normal intestinal tissues(t=5.84, P<0.05). Conclusion The positive expression of circ-92400 is closely correlated with tumor size, lymph node metastasis, TNM stage and degree of differentiation, and circ-92400 may be a new tumor marker of colorectal adenocarcinoma.
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出版历程
  • 收稿日期:  2020-05-27
  • 网络出版日期:  2020-09-14

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