Occurrence of sarcopenia in maintenance hemodialysis patients and its influencing factors
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摘要: 目的 探讨维持性血液透析(MHD)患者肌少症发生情况及其影响因素。 方法 选取55例MHD患者作为研究对象,应用生物电阻抗法测量患者四肢骨骼肌量,依据公式计算相对骨骼肌质量指数(RSMI), 采用电子握力计测量肌力,并收集患者的一般资料和实验室检查指标结果。评估MHD患者肌少症患病情况,并分析相关影响因素。 结果 本组MHD患者的肌少症患病率为40.00%; 肌少症组和无肌少症组患者在年龄、体质量指数(BMI)及体蛋白质含量方面比较,差异有统计学意义(P<0.05或P<0.01)。多因素Logistic回归分析显示,年龄(OR=0.907, 95%CI为0.832~0.988, P=0.026)、BMI(OR=1.674, 95%CI为1.166~2.404, P=0.005)、蛋白质含量(OR=2.716, 95%CI为1.394~5.298, P=0.003)是MHD患者发生肌少症的独立影响因素。 结论 MHD患者的肌少症发病率较高,年龄、BMI及体蛋白质含量是患者发生肌少症的独立影响因素,对老年患者应尽早评估肌少症发生情况,适当提高BMI及体蛋白质含量对于减少肌少症的发生有重要意义。Abstract: Objective To explore the prevalence of sarcopenia in maintenance hemodialysis(MHD)patients and its influencing factors. Methods A total of 55 MHD patients were selected as research objects. Bioelectrical impedance analysis was used to measure appendicular skeletal muscle mass, and relative skeletal muscle mass index(RSMI)was calculated according to formula. Electronic grip strength meter was used to measure the muscle strength, and the general data and laboratory examination indexes of two groups were collected. The prevalence and influencing factors of sarcopenia in MHD patients were evaluated. Results The prevalence rate of sarcopenia was 40.00%. Age, body mass index(BMI)and body protein content in the sarcopenia group and the non-sarcopenia group showed statistically significant differences(P<0.05 or P<0.01). Multiple Logistic regression analysis showed that age(OR=0.907, 95%CI from 0.832 to 0.988, P=0.026), BMI(OR=1.674, 95%CI from 1.166 to 2.404, P=0.005)and protein(OR=2.716, 95%CI from 1.394 to 5.298, P=0.003)were independent influencing factors of sarcopenia in MHD patients. Conclusion MHD patients have higher prevalence of sarcopenia. Age, BMI and protein are independent influencing factors. For elderly patients, it is of great significance to early evaluating occurrence of sarcopenia and increasing the level of BMI and protein so as to reduce the incidence of sarcopenia.
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Keywords:
- maintenance hemodialysis /
- sarcopenia /
- influencing factors
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