Effect of self-made Tonifying Liver and Kidney Decoction and levodopa in combination on anxiety score and sleep score in patients with Parkinson's disease
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摘要: 目的 探讨自拟补益肝肾汤联合左旋多巴对帕金森病的治疗效果。 方法 选取80例帕金森病患者作为研究对象,按照入院顺序分成对照组和观察组。对照组采用左旋多巴治疗,观察组在此基础上联合使用自拟补益肝肾汤。比较2组疾病治疗情况。 结果 治疗前,对照组和观察组病情严重程度、焦虑情绪和睡眠情况比较,差异无统计学意义(P>0.05); 治疗后,观察组帕金森病自主神经症状量表(SPOCA-AUT)、统一帕金森病评分量表(UPDRS)和Zung氏焦虑自评量表(SAS)评分低于对照组,帕金森病睡眠量表(PDSS)评分高于对照组,差异有统计学意义(P<0.05); 观察组用药后不良反应发生率低于对照组,生活质量评分高于对照组,差异有统计学意义(P<0.05)。 结论 在帕金森病患者的治疗中联合使用自拟补益肝肾汤,治疗效果好,安全性高。Abstract: Objective To investigate the therapeutic effect of self-designed Tonifying Liver and Kidney Decoction and levodopa in combination for Parkinson's disease. Methods A total of 80 patients with Parkinson's disease were selected in the study, and were divided into control group and observation group according to admission order. The control group was given levodopa for treatment, and the observation group received self-made Tonifying Liver and Kidney Decoction based on the control group. The treatment conditions of the two groups were compared. Results There were no differences between the control group and the observation group in severity, anxiety and sleep conditions before treatment(P>0.05), while the Autonomic Nerve Symptom Scale for Parkinson's disease(SPOCA-AUT), Unified Parkinson's Disease Rating Scale(UPDRS)and Zung's Self-rating Anxiety Scale(SAS)scores of the observation group after treatment were lower than those in the control group, while the Parkinson's Disease Sleep Scale(PDSS)score was higher than that in the control group(P<0.05). The incidence of drug related adverse reactions in the observation group was significantly lower, and the quality of life score was significantly higher than that in the control group(P<0.05). Conclusion Self-designed Tonifying Liver and Kidney Decoction and levodopa in combination has good effect and high safety in the treatment of Parkinson's disease.
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Keywords:
- Tonifying Liver and Kidney Decoction /
- levodopa /
- Parkinson's disease /
- anxiety /
- sleep score /
- quality of life
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