Abstract: Objective To investigate the effect of curettage combined with norethindrone on endometrial thickness in patients with menopausal dysfunctional uterine bleeding. Methods Totally 85 patients with menopausal dysfunctional uterine bleeding were randomly divided into observation group(n=42)and control group(n=43), all given curettage. Control group was treated with curettage and mifepristone, while observation group was treated with curettage and norethindrone. The estrogen level, endometrial thickness and the incidence of adverse reactions were compared between two groups. Results After treatment, the levels of estradiol(E₂), progesterone(P)and luteinizing hormone(LH)in the observation group were significantly lower than those in the control group(P<0.05). After treatment, the endometrial thickness of observation group was significantly smaller than that in control group(P<0.05). There was no significant difference in the incidence of adverse reactions between two groups(P>0.05). Conclusion For patients with menopausal dysfunctional uterine bleeding, curettage combined with norethindrone can improve estrogen level and decrease endometrial thickness.