Abstract: Objective To investigate the efficacy of levocarnitine combined with nutrient therapy in the treatment of idiopathic asthenospermia in males with infertility. Methods A total of 72 infertility males with idiopathic asthenospermia were recruited as study objects, and were divided into observation group and control group according to different treatment plans, with 36 cases in each group. The control group was treated with routine vitamin E and coenzyme Q10, and the observation group was treated with levocarnitine combined with nutrient therapy. The semen parameters of two groups were observed after 3 months of treatment, and the clinical efficacy was comprehensively evaluated. Results After treatment, semen volume, sperm concentration, sperm motility, sperm DNA integrity rate and normal morphology sperm rate in the two groups were better than pre-treatment, and the above indicators in the observation group were significantly better than those in the control group(P<0.05). Conclusion Combination of levocarnitine and nutrient therapy in the treatment of infertility men with idiopathic asthenozoospermia has reliable efficacy and can significantly improve the quality of semen.