Efficiency evaluation of norethisterone combined with Bushen Guchong Zhixue Recipe in treatment of patients with dysfunctional uterine bleeding
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摘要: 目的 探讨炔诺酮联合补肾固冲止血方治疗功能失调性子宫出血患者的疗效。 方法 将96例功能失调性子宫出血患者随机分为2组各48例。对照组给予炔诺酮治疗,研究组给予炔诺酮联合补肾固冲止血方治疗。比较2组雌激素水平［雌二醇(E2)、促卵泡生成素(FSH)、促黄体生成素(LH)］、子宫内膜厚度、血红蛋白水平、临床疗效及不良反应发生情况。 结果 治疗后, 2组E2、FSH、LH低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。治疗后, 2组血红蛋白水平均高于治疗前,且研究组显著高于对照组(P<0.05); 2组子宫内膜厚度均小于治疗前,且研究组显著小于对照组(P<0.05)。研究组中医症状改善总有效率为95.83%,显著高于对照组的81.25%(P<0.05)。研究组不良反应发生率为6.25%, 对照组为10.42%,差异无统计学意义(P>0.05)。 结论 益气固冲补肾方联合炔诺酮治疗功能失调性子宫出血安全、有效,可改善患者雌激素水平,提高血红蛋白含量,减小子宫内膜厚度。Abstract: Objective To explore the therapeutic effect of norethisterone combined with Bushen Guchong Zhixue Recipe in treatment of patients with dysfunctional uterine bleeding. Methods Totally 96 patients with dysfunctional uterine bleeding were randomly divided into two groups, with 48 cases in each group. The control group was treated with norethisterone, and the study group was treated with norethisterone and Bushen Guchong Zhixue Recipe. Levels of estrogen indexes ［estradiol(E2), follicle stimulating hormone(FSH), luteinizing hormone(LH)］, endometrial thickness, hemoglobin level, clinical efficacy and adverse reactions were compared between the two groups. Results After treatment, E2, FSH and LH levels in both groups were significantly lower than those before treatment, and the indexes in study group were significantly lower than the control group(P<0.05). After treatment, the hemoglobin levels in both groups were significantly higher than that before treatment, and the hemoglobin level in study group was significantly higher than that in the control group(P<0.05). After treatment, the endometrial thickness in both groups was significantly smaller than that before treatment, and the endometrial thickness in study group was significantly smaller than that in the control group(P<0.05). The total effective rate of TCM symptom improvement in the study group was 95.83%, which was significantly higher than 81.25% in the control group(P<0.05). The incidence of adverse reactions was 6.25% in the study group and 10.42% in the control group, - and there was no significant difference between two groups(P>0.05). Conclusion Norethisterone combined with Bushen Guchong Zhixue Recipe is safe and effective in the treatment of patients with dysfunctional uterine bleeding, which can improve the estrogen level, increase the content of hemoglobin and reduce the endometrial thickness.
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杨雪琳, 马英杰, 王莹, 等. 丝瓜络不同炮制品治疗功能失调性子宫出血的药效比较[J]. 山东中医杂志, 2018, 37(9): 772-774. 黄德良, 戴炜. 炔诺酮致急性药物性肝损伤1例报告[J]. 临床肝胆病杂志, 2018, 34(6): 1294-1295. 卢春梅. B超联合个性化选择药物治疗无排卵型功能失调性子宫出血疗效分析[J]. 西北国防医学杂志, 2018, 39(1): 21-23. 王丽. 复方炔诺酮片联合戊酸雌二醇在功能失调性子宫出血治疗中的疗效观察[J]. 临床医学研究与实践, 2017, 2(24): 102-103. 初永丽, 郭玉华, 李爱清, 等. 新编实用妇产科学[M]. 北京: 第二军医大学出版社, 2010: 55-58. 中华中医药学会. 中医妇科常见病诊疗指南[M]. 北京: 中国中医药出版社, 2012: 33-35. 国家药品监督管理局. 中药新药临床研究指导原则[M]. 北京: 中国医药科技出版社, 2002: 51-54. 胡慧, 王萍玲, 梁文通, 等. 诺舒手术治疗功能失调性子宫出血的有效性及安全性研究[J]. 中国妇产科临床杂志, 2019, 20(2): 172-173. 陈志霞, 黄健玲. 黄健玲教授治疗功能失调性子宫出血经验[J]. 世界中西医结合杂志, 2019, 14(6): 795-797 , 801.
郑会贤. 培坤丸联合左炔诺孕酮治疗围绝经期功能失调性子宫出血的疗效观察[J]. 现代药物与临床, 2019, 34(6): 1797-1800. 申铁英. 小剂量米非司酮联合补肾固冲汤治疗围绝经期功能失调性子宫出血的临床效果[J]. 世界中西医结合杂志, 2017, 12(4): 538-540. 常君花. 米非司酮联合炔诺酮治疗复发性功能失调性子宫出血的效果探讨[J]. 当代医药论丛, 2017, 15(22): 170-171. 刘柳青, 忻凌, 经燕. 基于医案及数据挖掘的叶天士治疗崩漏用药规律研究[J]. 辽宁中医药大学学报, 2018, 20(10): 182-186. 冀麟麟, 王欣, 钟祥健, 等. 山茱萸的化学成分及其抗氧化活性[J]. 现代食品科技, 2019, 35(5): 137-143 , 36.
吕建军, 郝瑞春, 门九章. 含熟地黄成方制剂证治用药规律挖掘研究[J]. 国际中医中药杂志, 2018, 40(6): 517-521. 廖凤霞, 贺洪琼, 杨红涛, 等. 不同年份阿胶中5种成分的同时测定[J]. 中成药, 2018, 40(4): 988-990. 张茂婷, 杨柳, 胡江苗, 等. 茜草地上部分木脂素类成分研究[J]. 中草药, 2017, 48(23): 4856-4859. 翟琪, 王燕, 刘荣. 补肾固冲止血方联合炔诺酮片治疗围绝经期功能失调性子宫出血临床疗效及对性激素和子宫内膜厚度的影响[J]. 河北中医, 2019, 41(6): 822-826 , 832.
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