Abstract: Objective To explore the effect of flupentixol and melitracen tablets combined with Tianmeng Oral Liquid on sleep quality and negative emotions of insomnia patients with anxiety. Methods Eighty-four patients with insomnia and anxiety were selected and randomly divided into two groups, with 42 cases in each group. Control group was treated with flupentixol and melitracen tablets, while the study group was additionally treated with Tianmeng Oral Liquid on the basis of the control group. Pittsburgh Sleep Quality Index(PSQI)score, Hamilton Anxiety Scale(HAMA)score, comfort score, clinical efficacy and incidence of adverse reactions were compared between the two groups. Results After treatment, the score of each item and total score of PSQI in the study group were significantly lower than those in the control group(P<0.05). After 1 week, 2 and 4 weeks of treatment, the HAMA score of the study group was significantly lower than that of the control group(P<0.05), and the comfort score was significantly higher than that of the control group(P<0.05). The total effective rate of the study group was significantly higher than that of the control group(P<0.05). There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05). Conclusion For insomnia patients with anxiety, flupentixol and melitracen tablets combined with Tianmeng Oral Liquid can improve the clinical symptoms of patients, and has a higher safety.