消化道肿瘤患者癌性相关性贫血的影响因素分析

周宗斌; 赵桂芬; 兰文权; 李远发; 周志刚

doi:10.7619/jcmp.202008016

消化道肿瘤患者癌性相关性贫血的影响因素分析

1. 长江大学附属仙桃市第一人民医院消化内科, 仙桃湖北, 433000;
2. 湖北省仙桃市疾控中心, 湖北仙桃, 433000

详细信息

通讯作者:
周志刚,E-mail:70297779@qq.com

中图分类号: R735
计量
- 文章访问数: 460
- HTML全文浏览量: 144
- PDF下载量: 7
出版历程
- 收稿日期: 2019-12-19

Analysis of influencing factors of cancer-related anemia in digestive tract tumor patients

1. Digestion Department of Internal Medicine, Xiantao City First People's Hospital Affiliated to Yangtze University, Xiantao, Hubei, 433000;
2. Xiantao City Disease Control and Prevention Center, Xiantao, Hubei, 433000

摘要

摘要: 目的探讨消化道肿瘤患者癌性相关性贫血的影响因素。方法选择消化道肿瘤患者200例为研究对象,分析癌性相关性贫血的发生情况。患者癌性相关性贫血的影响因素采用单因素分析,危险因素采用Logistic多因素回归分析。结果 200例消化道肿瘤患者中,癌性相关性贫血124例(62.00%), 其中轻度32例,中度64例,重度16例,极重度12例。单因素分析结果表明, 2组性别、体质量指数、吸烟、饮酒及合并基础疾病比较,差异无统计学意义(P>0.05); 2组年龄、TNM分期、Karnofsky功能状态(KPS)评分、低蛋白血症和抗肿瘤治疗比较,差异有统计学意义(P<0.05)。Logistic多因素回归分析显示,年龄>60岁、Ⅲ~Ⅳ期、KPS评分>60分、低蛋白血症和抗肿瘤治疗为影响癌性相关性贫血的危险因素。结论消化道肿瘤癌性相关性贫血发生率较高,以轻中度为主,其中年龄>60岁、TNM分期Ⅲ~Ⅳ期、KPS评分>60分、低蛋白血症和抗肿瘤治疗为癌性相关性贫血的危险因素。
- 消化道肿瘤 /
- 癌性相关性贫血 /
- 危险因素 /
- 单因素分析 /
- Logistic多因素回归分析
Abstract: Objective To investigate influencing factors of cancer-related anemia in digestive tract tumor patients. Methods A total of 200 digestive tract tumor patients were selected as the research objects, and the occurrence of cancer-related anemia was analyzed. The influencing factors affecting cancer-related anemia were analyzed by univariate analysis, and risk factors were analyzed by Logistic multivariate regression analysis. Results Out of 200 patients with digestive tract tumors, 124 cases had cancer-related anemia(62.00%), including 32 mild cases, 64 moderate cases, 16 severe cases and 12 extremely severe cases. Univariate analysis showed that there were no significant differences in gender, body mass index, smoking, alcohol drinking and complicating with basic diseases between the two groups(P>0.05); there were significant differences in age, TNM stage, Karnofsky Performance Status(KPS)score, hypoproteinemia and antineoplastic treatment between the two groups(P<0.05). Logistic multivariate regression analysis showed that patients aged over 60 years, at stage of Ⅲ or Ⅳ, with KPS scoring>60, hypoproteinemia and antineoplastic therapy were risk factors for cancer-related anemia. Conclusion The incidence of cancer-related anemia in digestive tract is relatively high, occurring mainly in mild to moderate patients. Over 60 years of age, Ⅲ or Ⅳ staging in TNM stage, KPS scoring over 60, hypoproteinemia and anti-cancer treatment are risk factors for cancer-related anemia.
- digestive tract cancer /
- cancer-related anemia /
- risk factors /
- univariate analysis /
- Logistic multivariate regression analysis

HTML全文

参考文献(20)

Walker M S, Pohl G M, Houts A C, et al. Analysis of the psychological impact of cancer-related symptoms on patients with non-small cell lung cancer[J]. Psycho-Oncology, 2017, 26(6): 755-762.

Finkelstein F O, Nooten F V, Wiklund I, et al. Measurement properties of the Short Form-36(SF-36)and the Functional Assessment of Cancer Therapy-Anemia(FACT-An)in patients with anemia associated with chronic kidney disease[J]. Health & Quality of Life Outcomes, 2018, 16(1): 111.

赵琴. 癌性贫血对肿瘤患者生活质量的影响[J]. 临床护理杂志, 2017, 21(1): 63-65.

宋志刚, 汪济东, 孙琦, 等. 结直肠癌相关性贫血的机制及治疗[J]. 现代仪器与医疗, 2017, 23(5): 68-70.

刘昊. 贫血与肺癌患者预后的相关性[J]. 肿瘤研究与临床, 2017, 29(7): 463.

孙婷婷, 张晓晔. 155例肿瘤患者癌性贫血的相关因素分析[J]. 现代肿瘤医学, 2016, 24(5): 782-786.

杨环, 张宜琪, 王凯, 等. 胃肠道肿瘤合并癌性贫血患者外周血铁调素水平、白细胞介素-6、IFN-γ及TNF-α的浓度变化[J]. 实用癌症杂志, 2016, 31(12): 1933-1935.

程旭, 陆晔, 李蓉, 等. 铁调素调节蛋白、骨形成蛋白6及铁调素在乳腺癌组织中的表达及其与贫血的关系[J]. 医学研究杂志, 2017, 46(11): 149-152.

叶秀萍, 黄珍珍, 洪小芳. 宫颈癌中重度贫血患者围手术期的护理及预防对策[J]. 护士进修杂志, 2018, 33(20): 66-68.

陆志萍, 周扬. 以贫血为首发症状的胃癌患者的临床病理特征与预后分析[J]. 医学理论与实践, 2017, 30(17): 2510-2512.

王博, 陈焕伟, 吕学文, 等. 贫血与晚期宫颈癌化疗疗效的相关性[J]. 现代肿瘤医学, 2018, 26(2): 285-288.

马继利. 重组人促红细胞生成素对胃癌相关性贫血患者治疗效果的影响[J]. 医疗装备, 2017, 30(10): 117-118.

王雪冰, 李康. 自拟生血方加减治疗非小细胞肺癌相关性贫血临床疗效观察[J]. 中华中医药学刊, 2017, 13(9): 2401-2403.

莫淑婵, 田甜, 吴钟彪. 升血汤对转移性结直肠癌化疗患者免疫功能及相关性贫血的影响[J]. 中医药导报, 2018, 12(1): 70-72.

杨斌, 张建武. 酶联免疫吸附法测定肿瘤性贫血患者的血清细胞因子水平及其发病机制研究[J]. 中国临床药理学杂志, 2017, 33(12): 1102-1105.

王希, 夏冰, 张翼鷟. 肿瘤相关性贫血研究进展[J]. 中国肿瘤临床, 2018, 45(14): 759-762.

魏佳宁, 王凤, 卢蕻迪, 等. 149例老年患者肿瘤相关性贫血的临床分析[J]. 中国实验诊断学, 2018, 22(5): 109-111.

邱春凤. 重组人红细胞生成素对恶性肿瘤患者贫血及睡眠的影响[J]. 世界睡眠医学杂志, 2017, 4(6): 352-354.

陈慧莉, 师文静, 姜飞. 晚期恶性肿瘤相关缺铁性贫血调查及静脉铁剂治疗观察[J]. 中国继续医学教育, 2018, 10(14): 143-145.

陆秋云, 唐华英, 黄迎春, 等. 支持性护理干预联合Orem自理模式对妇科恶性肿瘤病人癌性贫血及生活质量的影响[J]. 护理研究, 2018, 32(16): 96-100.

施引文献(10)

期刊类型引用(8)

1.	陈斌妮，杨柳，张保根. 结肠癌病人并发贫血的危险因素分析及护理观察. 全科护理. 2025(02): 199-202 . 百度学术
2.	聂义丹，杨峰，冯富鹏. HRR对UTUC术后膀胱复发的预测效能. 国际泌尿系统杂志. 2024(06): 1033-1036 . 百度学术
3.	彭恋，张坤贤. 结直肠癌患者围术期发生贫血风险预测模型的建立及验证. 安徽医学. 2022(03): 337-340 . 百度学术
4.	程媛媛，彭海燕，胡利兵. 腮腺腺淋巴瘤与多形性腺瘤的CT表现及吸烟者比例、吸烟指数差异分析. 河北医科大学学报. 2022(05): 583-586 . 百度学术
5.	吴雨燕，程珍，潘湘涛. 手术、化疗和放疗对胃癌患者营养状态的影响及与贫血发生、发展的关系研究. 中国实用医药. 2022(21): 34-37 . 百度学术
6.	刘韵，王智浩，曹如柔，蒋帆，蒋益兰. 蒋益兰运用祛瘀生新法治疗肿瘤相关性贫血经验. 湖南中医杂志. 2021(04): 30-32 . 百度学术
7.	周海平，王瑶，朱慧民，秦海霞. 炙甘草汤联合针灸治疗老年肿瘤相关性贫血临床观察. 辽宁中医杂志. 2021(11): 132-134 . 百度学术
8.	高玉海，魏云海，蔡炜龙，魏强，韩书文. 术前ALB-Hb评分预测Ⅱ～Ⅲ期结直肠癌患者预后的价值. 浙江医学. 2021(22): 2407-2410 . 百度学术