Abstract: Objective To compare the effect of transcatheter arterial chemoembolization associated with domestic CalliSpheres drug-loaded microspheres(DEB-TACE)and conventional transcatheter arterial chemoembolization(cTACE)in treatment of patients with hepatic malignant tumor. Methods A total of 88 patients with hepatic malignant tumor were selected and randomly divided into cTACE group(n=49)and DEB-TACE group(n=39)according to different surgical progran. The short-term efficacy and the incidence of acute adverse reactions were compared between the two groups. After 2 years of follow-up, the survival rate without tumor recurrence and total survival rate at time points of 0.5, 1, 1.5 and 2 years after operation were compared between the two groups. Results After treatment, the disease remission rate and disease control rate of DEB-TACE group were significantly higher than those of cTACE group(P<0.05). There was no significant difference in incidence of acute adverse reactions between the two groups(P>0.05). The survival rate without tumor recurrence and total survival rate in DEB-TACE group were significantly higher than those in cTACE group(P<0.05). Conclusion DEB-TACE can significantly improve the short-term effect, the survival rate without tumor recurrence and total survival rate of hepatic malignant tumor patients who can not be treated by surgery, and its safety is higher.