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老年糖尿病患者颈动脉斑块形成与血糖水平相关性研究

Relationship between carotid plaque formation and bloodglucose level in elderly patients with diabetes mellitus

    摘要
  • 摘要:
      目的  探讨老年糖尿病患者颈动脉斑块形成与血糖水平的关系。
      方法  选择老年糖尿病患者84例，均行彩色多普勒超声，根据颈动脉斑块情况分为有斑块组与无斑块组。有斑块组根据斑块等级又分为斑块Ⅰ级组、Ⅱ级组、Ⅲ级组。测定患者糖化血红蛋白(HbA1c)、空腹血糖(FPG)、餐后2 h血糖水平。分析血糖水平对颈动脉斑块形成的影响。
      结果  有斑块组的HbA1c、FPG、餐后2 h血糖水平均高于无斑块组，差异有统计学意义(P < 0.05)。斑块Ⅱ级组、Ⅲ级组的HbA1c、FPG、餐后2 h血糖均高于斑块Ⅰ级组(P < 0.05), 随着斑块严重程度的增加，血糖水平逐渐升高。
      结论  老年糖尿病患者血糖水平与颈动脉斑块的发生、发展具有相关性，血糖控制良好有助于延缓动脉硬化的进展。

     

    Abstract:
      Objective  To investigate relationship between carotid plaque formation and blood glucose level in elderly patients with diabetes mellitus.
      Methods  A total of 84 elderly patients with diabetes mellitus were collected and conducted with color Doppler ultrasound. According to the status of carotid plaque, the patients were divided into plaque group and non-plaque group. According to the plaque grade, the plaque group was divided into grade Ⅰ group, grade Ⅱ group and grade Ⅲ group. Glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG) and 2 hours postprandial blood glucose were measured. The effect of blood glucose level on carotid plaque formation was analyzed.
      Results  HbA1c, FPG and 2 hours postprandial blood glucose in the plaque group were significantly higher than those in the non-plaque group (P < 0.05). HbA1c, FPG and 2 hours postprandial blood glucose in grade Ⅱ and grade Ⅲ plaque groups were significantly higher than those in grade Ⅰ plaque group (P < 0.05). With the increase of plaque severity, the blood glucose level gradually increased.
      Conclusion  There is a correlation between the level of blood glucose and the occurrence and development of carotid plaque in elderly diabetic patients. Good blood glucose control is helpful to delay the progress of atherosclerosis.

     

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