Abstract: Objective To observe the curative effect of rosuvastatin on treatment of elderly patients with type 2 diabetes mellitus complicated with coronary heart disease.Methods A total of 86 patients with type 2 diabetes mellitus complicated with coronary heart disease were divided into observation group (n =45,rosuvastatin plus conventional therapy) and control group (n =41,conventional treatment).After 12 weeks of treatment,the therapeutic effect was observed.Results After treatment,in the observation group,the LDL-C and TC significantly reduced,and were significantly lower than the control group (P ＜ 0.05).Level of HDL-C increased significantly in the observation group,and was significantly higher than the control group (P ＜ 0.05).After treatment,the levels of IL-6 and CRP in the peripheral blood of the observation group were significantly lower than those of the control group (P ＜ 0.05).After treatment,in the observation group,the NO and LVEF increased significantly,and were significantly higher than the control group (P ＜ 0.05).The level of ET in the observation group decreased significantly,and was significantly lower than the control group (P ＜ 0.05).In the observation group,the cumulative major adverse cardiac event rate was significantly lower than that of the control group (P =0.036).Conclusion Rosuvastatin can effectively improve the cardiovascular function in elderly patients with type 2 diabetes mellitus and coronary heart disease.