Efficacy of lienal polypeptide injection combined with conventional therapy in treatment of children with recurrent respiratory infection and their influence on immune function
-
摘要: 目的 观察并分析脾多肽联合常规治疗对反复小儿呼吸道感染的疗效及免疫功能影响.方法 将128例反复呼吸道感染患儿随机分成2组各64例.对照组患者采取常规治疗.观察组在对照组的基础上使用脾多肽注射液.随访6个月,记录6个月内呼吸道感染次数.观察2组患儿在治疗前后免疫球蛋白(IgA、IgM、IgG)以及T淋巴细胞(CD3+、CD4+、CD8+、CD4+/CD8+)的变化.结果 观察组患儿的总有效率显著高于对照组(P＜0.05).在治疗后,观察组患儿的IgA、IgM、IgG水平均显著提升(P＜0.05),而对照组治疗前后无显著变化(P＞0.05).观察组患儿的CD3+、CD4+和CD4+/CDs+在治疗后显著上升,CDs+显著下降(P＜0.05),而对照组的T淋巴细胞亚群在治疗前后均无显著变化(P＞0.05).结论 在常规治疗的基础上,采用脾多肽治疗小儿反复呼吸道感染,能显著提升临床疗效,改善患儿的免疫功能.Abstract: Objective To observe the efficacy of lienal polypeptide injection combined with conventional therapy in treatment of children with recurrent respiratory infection and their influence on immune function.Methods A total of 128 children with recurrent respiratory infection were randomly divided into observation group and control group.Control group was given conventional therapy.On the basis of control group,observation group was given additional lienal polypeptide injection.All the children were followed up for 6 months,and the occurrence of respiratory infection was recorded.The changes of IgA,IgM,IgG and CD3 +,CD4 +,CDs +,CD4 +/CDs + were observed.Results The total effective rate of the observation group was significantly higher than the control group (P ＜ 0.05).After treatment,the IgA,IgM and IgG levels of observation group increased significantly (P ＜ 0.05)while control group had no significant change (P ＞ 0.05).The CD3 +,CD4 +,CD4 +/CDs + of observation group increased significantly and CDs + decreased significantly after treatment (P ＜ 0.05),while control group had no significant change (P ＞ 0.05).Conclusion On the basis of conventional therapy,lienal polypeptide injection can improve the therapeutic effect and enhance the immune function in children with recurrent respiratory infection.
-
-
期刊类型引用(12)
1. 苗雪艳，彭韶，储卫红. 肠道菌群失调与RRTI患儿T淋巴细胞亚群、免疫球蛋白水平的关系. 海南医学. 2024(17): 2501-2505 . 
百度学术
2. 刘军，陈秋萍，毛晓玲，刘明. 探讨脾氨肽在儿童呼吸道反复感染不同类型中的作用. 药品评价. 2021(11): 695-697 . 百度学术
3. 邓春荣，姜静，任秀，张凯，于代华，范洪伟. 脾多肽对ICU呼吸机相关性肺炎患者细胞免疫功能和治疗效果的影响. 重庆医学. 2020(08): 1274-1278 . 百度学术
4. 朱长龙，韦红，马晓燕. 反复呼吸道感染患儿血清维生素A、E水平与T细胞免疫的关系研究. 中国儿童保健杂志. 2020(07): 798-801 . 百度学术
5. 崔洁媛，李春珍，张东风，袁小颖，刘玲，刘福娟. 脾多肽注射液辅助治疗儿童紫癜性肾炎的疗效. 中华临床医师杂志(电子版). 2020(08): 630-634 . 百度学术
6. 刘海芬. 阿奇霉素治疗儿童呼吸道感染的治疗效果. 世界最新医学信息文摘. 2019(15): 154+160 . 百度学术
7. 周寒丽，段方方，孔天东. 脾多肽联合化疗治疗对肺癌患者临床疗效和免疫功能的影响. 四川解剖学杂志. 2019(01): 86-87 . 百度学术
8. 李进，方代华. T淋巴细胞亚群与NK细胞在小儿支气管肺炎中的变化及意义. 广西医科大学学报. 2019(05): 785-788 . 百度学术
9. 唐庆，李少宁，詹文娟. 复可托治疗小儿反复肺炎支原体感染的疗效及对免疫功能和肺功能的影响. 广西医科大学学报. 2018(01): 33-37 . 百度学术
10. 崔卫国，崔圣莹. 脾多肽辅助甘草锌颗粒对慢性腹泻小儿血锌水平及免疫功能的影响. 泰山医学院学报. 2018(11): 1238-1240 . 百度学术
11. 刘靖，余南生，谢军. 脾多肽注射液联合芪黄益肺合剂治疗重症肺炎的疗效及对免疫功能的影响. 广东医学. 2018(21): 3266-3269 . 百度学术
12. 张磊，王耀邦，高凤，曹兴丽，侍响响. 阿奇霉素与免疫刺激剂脾多肽联合治疗支原体肺炎的疗效及对细胞免疫水平的影响. 中国妇幼保健. 2017(24): 6168-6171 . 百度学术
其他类型引用(1)
计量
- 文章访问数: 297
- HTML全文浏览量: 73
- PDF下载量: 4
- 被引次数: 13
下载:
苏公网安备 32100302010246号