Abstract: Obj ective To analyze the difference of positive expression rate of HBsAg and HBeAg among patients with malignant lymphoma,other tumor patients and normal people.Meth-ods A total of 260 patients were collected,including 102 cases in malignant lymphoma group,98 cases in other cancer group and 60 cases in normal group.Clinical materials of patients with malig-nant lymphoma were retrospectively analyzed.The differences of positive expression rate of HBsAg and HBeAg among patients with malignant lymphoma,other tumor patients and normal people were analyzed.The relationship between HBsAg,HBeAg and positive rate with age,gender,histological type,clinical stage were also analyzed.Results The positive expression rates of HBsAg and HBeAg in malignant lymphoma group were significantly higher than other cancer group and normal group.The positive expression rate of HBsAg and HBeAg had no significant correlation with age, gender,histological type,clinical stage.Conclusion The positive expression rates of HBsAg and HBeAg in malignant lymphoma patients are significantly higher than other cancer patients and nor-mal patients.