孕晚期妊娠糖尿病脂联素、瘦素、抵抗素水平与胰岛素抵抗的相关性研究

邢媛; 张聪

doi:10.7619/jcmp.201417022

孕晚期妊娠糖尿病脂联素、瘦素、抵抗素水平与胰岛素抵抗的相关性研究

邢媛,
张聪

南京医科大学附属南京妇幼保健院产科，江苏南京，210004

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中图分类号: R714.25
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- 发布日期: 2014-10-16

Correlation between levels of adiponectin, leptin,resistin and insulin resistance in gestational diabetes mellitus during third trimester

摘要

摘要: 目的：观察孕晚期妊娠糖尿病（GDM）患者的脂联素（ADP）、瘦素（LEP）、抵抗素水平及其与胰岛素抵抗（IR）的相互关系。方法选取2013年3月-2014年3月孕晚期GDM患者64例设为观察组，同期口服葡萄糖耐量试验正常的妊娠期妇女60例设为对照组，观察2组脂代谢相关指标、血ADP、LEP、抵抗素水平的差异及其与胰岛素抵抗指数（IRI）的相关性。结果观察组ADP水平显著低于对照组（P＜0．01），LEP、抵抗素水平及IRI显著高于对照组（P＜0．01）。相关性分析发现，ADP与IRI显著负相关，抵抗素与IRI显著正相关（P＜0．01）。结论妊娠晚期GDM患者的血LEP、抵抗素水平显著上升，ADP水平显著下降，LEP和抵抗素是影响IR的独立危险因子。
- 妊娠糖尿病 /
- 脂联素 /
- 瘦素 /
- 抵抗素 /
- 空腹血糖 /
- 口服葡萄糖耐量试验 /
- 胰岛素抵抗
Abstract: Objective To observe the relationship between levels of adiponectin(ADP),lep-tin(LEP),resistin and insulin resistance (IR)in the third trimester of gestation diabetes mellitus (GDM)patients.Methods 64 GDM patients were selected as observation group,while 60 normal pregnancy women without GDM were collected as control group.Differences of lipid metabolism related indexes,serum ADP,LEP,resistin levels between two groups were observed and analyzed for the cor-relation with insulin resistance index (IRI).Results Level of ADP in observation group was signifi-cantly lower than the control group (P<0.01 ),LEP,resistin and IRI were significantly higher than those in the control group (P<0.01).Correlation analysis showed ADP was negatively correlated with IRI and positively correlated with resistin and IRI (P<0.01 ).Conclusion Increasing of LEP,re-sistin and decreasing of ADP potentially shows a correlation with insulin résistance in GDM patients during third trimester,and LEP and resistin are two potential independent risk factors of IR.
- gestational diabetes mellitus /
- adiponectin /
- leptin /
- resistin /
- fasting blood glu-cose /
- oral glucose tolerance test /
- insulin resistance

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参考文献(15)

Boerschmann H, Pflüger M, Henneberger L. Prevalence and predictors of overweight and insulin resistance in offspring of mothers with gestational diabetes mellitus [J]. DIABETES CARE, 2010(8):1845.

Xiang A H, Kawakubo M, Trigo E. Declining β-Cell Compensation for Insulin Resistance in Hispanic Women With Recent Gestational Diabetes Mellitus Association with changes in weight, adiponectin, and C-reactive protein [J]. DIABETES CARE, 2010(2):396.

Mrkrid K, Jenum A K, Sletner L. Failure to increase insulin secretory capacity during pregnancy-induced insulin re-sistance is associated with ethnicity and gestational diabetes [J]. European Journal of Endocrinology, 2012(4):579.

美国糖尿病协会. 2012 年ADA糖尿病诊疗指南摘选 [J]. 浙江中西医结合杂志, 2013(7):600.

Saucedo R, Zarate A, Basurto L. Relationship between circulating adipokines and insulin resistance during pregnancy and postpartum in women with gestational diabetes [J]. Ar-chives of medical research, 2011(4):318.

张木勋, 杨雁, Katherine Cianflone. 2型糖尿病患者和甲状腺疾病患者血浆脂联素水平变化 [J]. 中华内分泌代谢杂志, 2005(1):59.doi: 10.3760/j.issn:1000-6699.2005.01.018.

Lacroix M, Battista M C, Doyon M. Lower adiponectin levels at first trimester of pregnancy are associated with in-creased insulin resistance and higher risk of developing gesta-tional diabetes mellitus [J]. DIABETES CARE, 2013(6):1577.

Cortés V A, Cautivo K M, Rong S. Leptin ameliorates insulin resistance and hepatic steatosis in Agpat2-/-lipodystro-phic mice independent of hepatocyte leptin receptors [J]. Jour-nal of lipid research, 2014(2):276.

Basoglu O K, Sarac F, Sarac S. Metabolic syndrome, insulin resistance, fibrinogen, homocysteine, leptin, and C-reactive protein in obese patients with obstructive sleep apnea syndrome [J]. Annals of thoracic medicine, 2011(3):120.

German J P, Wisse B E, Thaler J P. Leptin deficiency causes insulin resistance induced by uncontrolled diabetes [J]. DIABETES, 2010(7):1626.

刘登岩, 于健, 周素娴. 妊娠糖尿病患者抵抗素水平的改变及临床意义 [J]. 大连医科大学学报, 2008(4):334.

Mazaki-Tovi S, Kanety H, Pariente C. Insulin sensitivi-ty in late gestation and early postpartum period:the role of cir-culating maternal adipokines [J]. Gynecological Endocrinolo-gy, 2011(9):725.

Lobo T F, Torloni MR, Gueuvoghlanian-Silva B Y. Re-sistin concentration and gestational diabetes:a systematic re-view of the literature [J]. Journal of Reproductive Immunology, 2013(1):120.

施琦阳, 苏维娜, 黄凤凰. 妊娠糖尿病患者胰岛p细胞功能与相关脂肪细胞因子的关系 [J]. 福建医科大学学报, 2010(4):292.

赖丽萍, 陆泽元, 李翠吟. 孕晚期妊娠糖尿病脂联素、瘦素与胰岛素抵抗的相关性 [J]. 实用预防医学, 2012(8):1135.doi: 10.3969/j.issn.1006-3110.2012.08.006.

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孕晚期妊娠糖尿病脂联素、瘦素、抵抗素水平与胰岛素抵抗的相关性研究

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Correlation between levels of adiponectin, leptin,resistin and insulin resistance in gestational diabetes mellitus during third trimester

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