Abstract: Obj ective To explore the influence of atorvastatin intensive treatment on blood lipid and the level of serum high-sensitivity C-reactive protein (hs-CRP )and matrix metallopro-teinase (MMP-9)in patients with acute coronary syndrome (ACS).Methods A total of 131 pa-tients with ACS performed with percutaneous coronary intervention (PCI )in our hospital were se-lected and randomly divided into 2 groups,namely conventional group (63 cases )and intensive group (68 cases).Conventional group was given atorvastatin conventional treatment while intensive group was given atorvastatin intensive treatment.After 4 weeks,the level of blood lipid hs-CRP and MMP-9 and the occurrence of adverse reactions were recorded and the conditions of prognosis were observed.Results After 4 weeks,the levels of total cholesterol,triglyceride,low density lipoprotein,hs-CRP and MMP-9 in intensive group were lower than treatment before and control group (P<0.05,or P<0.01).High-density lipoprotein was significantly higher than treatment before and conventional group (P<0 .0 1 ).There was no adverse reactions in conventional group but slighter in intensive group,with good tolerance.At the end of the follow-up,the prognosis of intensive group was superior to conventional group (P<0 .05 ).Conclusion Compared with con-ventional treatment,atorvastatin intensive treatment has an better effect on ACS,capable of obvi-ously improving the clinical benefit of patients.