Abstract: Obj ective To observe the clinical effects of low molecular heparin calcium on hemorheology,N-terminal pro-brain natriuretic peptide (NT-proBNP)and blood plasma D-dipoly-mer (D-D)level in heart failure patients with pulmonary heart disease.Methods 95 heart failure patients with pulmonary heart disease were randomly divided into observation (n= 45 )and control groups (n= 50),both treated with regular treatment.Extra hypodermic injection of low molecular heparin calcium was given to observation group.Clinical effects,adverse events,hemorheology,N-terminal pro-brain natriuretic peptide (NT-proBNP)and blood plasma D-dipolymer (D-D)level were observed.Results Effective rate in observation group (95 .56%)was significantly higher than in control group (82.00%)(P<0.05),and significant difference was found in adverse events. Hemorheology,N-terminal pro-brain natriuretic peptide (NT-proBNP)and blood plasma D-dipoly-mer (D-D)level were improved in both groups after treatment (P<0.05,P<0.01),and differ-ences between 2 groups were significant (P<0.05,P<0.01).Conclusion Low molecular hep-arin calcium combined with dobutamine and magnesium sulfate has the potential to improve the hemorheology,N-terminal pro-brain natriuretic peptide (NT-proBNP)and blood plasma D-dipoly-mer (D-D)level in heart failure patients with pulmonary heart disease.